Synthesis and Evaluation of an Amphiphilic Polymer-based PDT Photosensitizer

doi:10.7517/j.issn.1674-0475.2016.05.426

Abstract

Abstract:

We designed and synthesized anamphiphilic polymer-based PDT photosensitizer PDPA-AMA-BOD. Experimental results demonstrated that PDPA-AMA-BOD could self-assemble into micelles in neutral aqueous environment and thus enabled the BODIPY photosensitizer trapped within the hydrophobic interior, which induced a high local concentration of BODIPY. As such, the efficiency of ¹O₂ generation was reduced by homo-FRET effect. In contrast, the protonation of amino sites attached to the hydrophobic end of PDPA-AMA-BOD resulted in the polymer well-dispersing in acidic aqueous solutions. As a consequence, concentration induced inhibition of ¹O₂ production was abolished. In this way, PDPA-AMA-BOD showed the acidity-controlled production of ¹O₂, suggesting the potential application as a selective PDT photosensitizer towards acidic tumor microenvironment.

Key words: amphiphilic polymer, photosensitizer, micelle, ¹O₂, photodynamic therapy

LUO Sihang, ZHAO Chunchang. Synthesis and Evaluation of an Amphiphilic Polymer-based PDT Photosensitizer[J]. Imaging Science and Photochemistry, 2016, 34(5): 426-434.

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