Imaging Science and Photochemistry ›› 2017, Vol. 35 ›› Issue (4): 445-463.DOI: 10.7517/j.issn.1674-0475.2017.04.008

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New Progress Design and Synthesis of Versatile Polymer Nanoparticles as Phototheranostics for Cancer

GUO Liang, GE Jiechao   

  1. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China
  • Received:2017-06-11 Revised:2017-06-22 Online:2017-07-15 Published:2017-07-15

Abstract:

Conjugated polymer nanoparticles (PNPs), which consist of π-conjugated organic polymers, are novel organic nanomaterials with the size in the range of 1-100 nm. Compared with the traditional organic small molecules, semiconductor quantum dots and inorganic nanomaterials, the PNPs show great potential applications in biological imaging, sensing and detection, drug delivery and theranostic, due to its advantages of special optical properties, diverse structure, easy surface modification and good biocompatibility. In this paper, we present a review of current development in PNPs, including their preparation, properties, and biocompatibility. Significantly, we summarized the new progress in preparation of versatile PNPs as phototheranostics for cancer, the problems needed to solve in future.

Key words: polymer nanoparticle, phototheranostics, fluorescence imaging, photoacoustic imaging, photodynamic therapy, photothermal therapy