The Preparation of Dual Targeting CdTe Quantum Dots and Its Application in Cells Labeling

doi:10.7517/j.issn.1674-0475.2017.05.004

Imaging Science and Photochemistry ›› 2017, Vol. 35 ›› Issue (6): 780-787.DOI: 10.7517/j.issn.1674-0475.2017.05.004

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The Preparation of Dual Targeting CdTe Quantum Dots and Its Application in Cells Labeling

YANG Dongzhi^1,2, WANG Wenwen², DU Yan^1,2, JI Haixia^1,2

1. Department of Pharmaceutical Analysis, Xuzhou Medical University, Xuzhou 221004, Jiangsu, P. R. China;
2. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, P. R. China

Received:2016-12-09 Revised:2017-01-10 Online:2017-11-15 Published:2017-11-15

Abstract

Abstract:

The pH sensitive CdTe quantum dots (QDs) were prepared with thioglycolic acid (TGA) and mercapto-acetohydrazide (TGH) as the stabilizers. After being conjugated with antibody, the prepared CdTe QDs has both functions of pH sensitivity and immune recognition. The results of fluorescence luminescence (FL), transmission electron microscopy (TEM) and cells labeling imaging showed that antibody was successfully conjugated on the surface of CdTe QDs. The prepared dual targeting QDs can be used to identify the acidic interstitial extracellular environment and label tumor cells specifically.

Key words: CdTe quantum dots, pH sensitivity, immune recognition

YANG Dongzhi, WANG Wenwen, DU Yan, JI Haixia. The Preparation of Dual Targeting CdTe Quantum Dots and Its Application in Cells Labeling[J]. Imaging Science and Photochemistry, 2017, 35(6): 780-787.

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The Preparation of Dual Targeting CdTe Quantum Dots and Its Application in Cells Labeling

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