Abstract: In this paper, the diagnostic value of CT combined with serum homocysteine (HCY) and beta 2-microglobulin (beta 2-M) in lower extremity arterial stenosis and occlusive disease was analyzed. 120 patients with suspected lower extremity artery stenosis and occlusive disease were selected as the study group, and 120 healthy people in the same period were selected as the control group, CT examination, serum HCY and β2-M levels examination were performed. CT diagnosis of lower extremity arterial stenosis and occlusion, the serum HCY and β2-M levels were compared. In this paper, the diagnostic values of CT, HCY, and β2-M in two groups were analyzed, and the misdiagnosis rate and missed diagnosis rate were also analyzed. The results showed that, among 120 patients, 646 lesions were detected by CT, including 155 slight stenosis, 257 moderate stenosis, 143 severe stenosis, and 91 complete occlusion; the levels of serum HCY and β2-M in the study group were significantly higher than those in the control group, the difference between the two groups was statistically significant (P<0.05). The AUC of HCY was 0.863, truncation value >21.75 (mol/L), diagnostic sensitivity was 79.00%, specificity was 80.00%, the AUC of β2-M was 0.837, truncation value >2.98 mol/mL, diagnostic sensitivity was 75.25%, specificity was 65.21%; the positive rate of CT diagnosis, HCY diagnosis, β2-M diagnosis, and three combined diagnosis were 67.50%, 69.17%, 67.50%, and 82.50%, respectively. The positive rate of combined diagnosis was higher than that of CT, HCY, and β2-M single diagnoses (P<0.05); CT, HCY, and β2-M single diagnoses had high sensitivity, specificity, and accuracy for lower extremity artery stenosis and occlusion disease, but the combined diagnosis of the three had the highest sensitivity, specificity, and accuracy, and the misdiagnosis rate and missed diagnosis rate were the lowest.

Key words: lower extremity arterial stenosis and occlusive disease, CT, homocysteine, β2-microglobulin