Imaging Science and Photochemistry ›› 2020, Vol. 38 ›› Issue (1): 87-93.DOI: 10.7517/issn.1674-0475.190716

• Review and Articles • Previous Articles     Next Articles

Effect of Panretinal Laser Photocoagulation Combined with Intravitreal Injection of Conbercept on Visual Function Recovery in Patients with Proliferative Diabetic Retinopathy

CHEN Ji   

  1. Department of Ophthalmology, Dazu District People's Hospital, Chongqing 402360, P. R. China
  • Received:2019-07-24 Online:2020-01-15 Published:2020-01-15

Abstract: To investigate the effect of PRP combined with intravitreal injection of Conbercept on visual function recovery in patients with proliferative diabetic retinopathy (PDR), 86 patients (86 eyes) with PDR were selected from August 2016 to August 2018. According to the treatment methods, they were divided into operation group and combination group, 43 cases each. The operation group was treated with PRP guided by fundus fluorescein angiography (FFA) with Carl Zeiss Meditec AG laser therapy instrument, while the combined group was treated with 0.1 mL of Conbercept injected into vitreous cavity 72 hours before operation. The visual acuity of the two groups was measured by ETDRS visual acuity meter, non-contact tonometer, optical coherence tomography (OCT) and FFA before and 4 months after operation. The incidence of postoperative complications in the two groups was analyzed. Four months after operation, the visual acuity and CMT of the two groups were changed compared with those before operation, and the vision of the combined group was significantly improved compared with that of the operation group, while CMT was significantly decreased compared with the operation group, with statistical significance (P<0.05). Retinal non-perfusion area and the disappearance rate of neovascularization in the combined group were significantly higher than those in the operation group (P<0.05). The incidence of complications such as retinal detachment, ocular hypertension and retinal hemorrhage was 4.65% in the combined group, which was significantly lower than 23.26% in the operation group (P<0.05). PRP combined with intravitreal injection of Conbercept in the treatment of PDR can significantly improve the visual acuity of patients, reduce CMT, promote the formation of no perfusion area or the regression of neovascularization, delay the proliferation of retinal neovascularization, improve visual function, and has high safety, which is worthy of clinical application.

Key words: proliferative diabetic retinopathy, panretinal laser photocoagulation, Conbercept, visual function