Abstract: To evaluate the plaque progression in patients with stable angina pectoris and its predictive value in cardiovascular events by coronary CTA, from January 2017 to December 2017, 142 patients with stable angina pectoris who underwent two coronary CT angiography follow-up visits due to new symptoms and aggravation of symptoms were selected as the study subjects. According to whether there were major adverse cardiac events in the follow-up group, 82 patients in the observation group with major adverse cardiac events were compared with 60 patients without major adverse cardiac events in the control group. Quantitative evaluation of plaque progression had been proceeded in patients with stable angina pectoris. The proportion of diabetes mellitus, hyperlipidemia and smoking history in the observation group was higher than that in the control group, and the difference was statistically significant (P<0.05). There were significant differences in CCTA total plaque load rate and coronary artery diameter stenosis rate between the two groups (P<0.05). And there were significant differences in plaque progression, lipid plaque load rate, fibrous plaque load rate, calcified plaque load rate, total plaque load rate and coronary artery diameter stenosis rate between the two groups (P<0.05). Multivariate logistic regression analysis showed that the progression of lipid plaque load was related to baseline hyperlipidemia (P<0.05). The overall progression of plaque load was correlated with baseline hyperlipidemia (P<0.05). The progression of coronary artery diameter stenosis was correlated with diabetes, hyperlipidemia and smoking history (P<0.05). In conclusion, CCTA is an effective method to detect the progression of plaque load in patients with stable angina pectoris, and cardiovascular risk factors can promote the progression of plaque load in patients with stable angina pectoris.

Key words: stable angina pectoris, coronary CTA, plaque progression, cardiovascular events