Imaging Science and Photochemistry ›› 2020, Vol. 38 ›› Issue (6): 956-961.DOI: 10.7517/issn.1674-0475.200503

• Review and Articles • Previous Articles     Next Articles

The Relationship Between FibroScan, Blood miR-21 Detection and the Degree of Liver Fibrosis in Patients with Hepatitis B Cirrhosis and the Predictive Value for Prognosis

LI Hongjiang1, HU Suling1, HE Jiusheng2, HE Fuliang3, LIU Zhenxia1   

  1. 1. Baoding People's Hospital, Baoding 071000, Hebei, P. R. China;
    2. Baoding Central Blood Station, Baoding 071000, Hebei, P. R. China;
    3. Beijing Friendship Hospital, Capital Medical University, Beijing 100050, P. R. China
  • Received:2020-05-12 Online:2020-11-15 Published:2020-11-15

Abstract: To investigate the relationship between FibroScan, blood miR-21 detection and the degree of liver fibrosis in patients with hepatitis B cirrhosis (HBC) and the value in predicting prognosis, 92 patients with HBC were selected as the case group, and 92 patients with chronic hepatitis B were selected as the control group. The results showed that the hardness value of the spleen and the liver, the level of blood miR-21, and the degree of liver fibrosis in the case group were higher than those in the control group. The spleen/liver stiffness values and blood miR-21 levels were positively correlated with the degree of liver fibrosis in HBC patients. The sensitivity of corresponding combined prediction was 68.42%, and specificity was 97.26%. After controlling the patient's baseline data such as age, body mass and gender, spleen/liver stiffness values and blood miR-21 were still important risk factors for the death of HBC patients (P<0.05). In conclusion, it is suggested that FibroScan parameters and changes of blood miR-21 levels are closely related to the degree of liver fibrosis and are independent risk factors for patients' death. The combined detection can provide a reference for the prognosis of clinical evaluation from the macro and micro levels.

Key words: FibroScan, miR-21, hepatitis B cirrhosis, liver fibrosis, spleen stiffness value