Imaging Science and Photochemistry ›› 2020, Vol. 38 ›› Issue (6): 1082-1087.DOI: 10.7517/issn.1674-0475.200603

• Review and Articles • Previous Articles     Next Articles

Predictive Value of Ultrasound Parameters Combined with Progesterone and β-hCG on Spontaneous Abortion in Early Pregnancy

FAN Hongyan, LIANG Tiantian   

  1. Haidian Maternal & Child Health Hospital, Beijing 100089, P. R. China
  • Received:2020-06-01 Online:2020-11-15 Published:2020-11-15

Abstract: 224 pregnant women were selected as the research object, followed up to 28 gestational weeks, and divided into abortion group and non-abortion group. The ultrasound parameters including fetal heart rate (FHR), crown-rump length (CRL), mean gestational sac diameter (MSD), mean sac diameter-crown-rump length (MSD-CRL) in early pregnancy of two groups were compared, as well as serum progesterone and β-hCG levels. Besides the influencing factors of spontaneous abortion, the correlation between ultrasound parameters and serum progesterone and β-hCG were analyzed too. In addition, the predictive value of the above indexes for spontaneous abortion was evaluated. The results showed that the FHR of the abortion group was lower than that of the non-abortion group, the MSD and MSD-CRL were shorter than that of the non-abortion group, and the serum progesterone and β-hCG levels were lower than that of the non-abortion group (P<0.05). The history of miscarriage, irregular intake of folic acid before and after pregnancy, husband smoking during pregnancy, FHR, MSD, MSD-CRL,progesterone, β-hCG in early pregnancy were important influencing factors for spontaneous abortion (P<0.05). FHR, MSD, MSD-CRL in early pregnancy were positively correlated with serum progesterone and β-hCG (P<0.05). The efficacy of FHR, MSD, MSD-CRL combined with serum progesterone and β-hCG on spontaneous abortion in early pregnancy was better than the above indicators alone. In conclusion, ultrasound parameters such as FHR, MSD, MSD-CRL and progesterone, β-hCG in early pregnancy are important influencing factors of spontaneous abortion, and the combined detection has good predictive value.

Key words: spontaneous abortion, early pregnancy, ultrasound parameters, progesterone, β-hCG