A Practical Synthesis of 2,4-Dichloro-3-Ethyl-6-Nitrophenol via TCIA

doi:10.7517/j.issn.1674-0475.2005.01.37

Imaging Science and Photochemistry ›› 2005, Vol. 23 ›› Issue (1): 37-40.DOI: 10.7517/j.issn.1674-0475.2005.01.37

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A Practical Synthesis of 2,4-Dichloro-3-Ethyl-6-Nitrophenol via TCIA

ZHAO Hong^1,2, SUN Jian², XU You-jun¹

1. School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, Liaoning, P. R. China;
2. Dalian Chemphy Chemical Co., Ltd., Dalian 116011, Liaoning, P. R. China

Received:2004-05-21 Revised:2004-07-23 Online:2005-01-23 Published:2005-01-23

Abstract

Abstract: 2,4-dichloro-3-ethyl-6-nitrophenol is an important intermediate for color film developer.We reported here a novel synthesis of the compound via TCIA chlorination,hydrolysis and acidification.Due to the easy handling of TCIA,the convenient detection for the process,this new chlorination method is very mild and echo-friendly and therefore cost-effective.When loaded with 1.5 mol (equivalence) of TCIA,the reaction proceeded smoothly in high yield and the tetrachloro by-product was effectively minimized.The solvents in the first two steps were recyclely used without severely affecting the results.

Key words: film developer, organic synthesis, chlorination, trichloroisocyanuric acid

CLC Number:

TN10.3
O32.3

ZHAO Hong, SUN Jian, XU You-jun. A Practical Synthesis of 2,4-Dichloro-3-Ethyl-6-Nitrophenol via TCIA[J]. Imaging Science and Photochemistry, 2005, 23(1): 37-40.

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A Practical Synthesis of 2,4-Dichloro-3-Ethyl-6-Nitrophenol via TCIA

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