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Table of Content

    15 July 2020, Volume 38 Issue 4
    Content
    2020, 38(4):  0-0. 
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    Review and Articles
    Recent Advances of the Near-infrared Fluorescent BODIPY/aza-BODIPY Dyes
    YUE Shuai, SHAO Zhumei, JIANG Xindong
    2020, 38(4):  585-600.  DOI: 10.7517/issn.1674-0475.191216
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    This review covers the design, synthesis and functionalization of BODIPY/aza-BODIPY as fluorophore probes since 2002, including applications for fluorescence quenching, metal ion, anion, biomolecular detection, etc. Synthesis, properties and application of novel aza-BODIPY, substituted aza-BODIPY on the boron center, new near-Infrared-fluorescent aza-BODIPY dyes with 1-methyl-1H-pyrrolyl substituents at the 3, 5-positions and so forth, were herein discussed.
    Fluorescent Sensing of Hg2+ by Phenanthroimidazole Derivative Supported on Silica Nanoparticles
    JIA Hongdan, XING Wenli, SONG Yujiao, ZHENG Shehong, GAO Yunyan, OU Zhize
    2020, 38(4):  601-608.  DOI: 10.7517/issn.1674-0475.200103
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    By using tetraethoxysilane (TEOS) and diethoxydimethylsilane (DEDMS) as starting materials, two silica nanoparticles SNP1 and SNP2 are prepared. SNP1 and SNP2 are characterized using transmission electron microscopy (TEM) and dynamic light scattering (DLS). The average diameters of SNP1 and SNP2 determined from the TEM image are about 13.5 nm and 25.9 nm. Dynamic light scattering (DLS) data show that the Zeta potentials of SNP1 and SNP2 are -5.74 mV and -2.28 mV, respectively. A turn-on fluorescence probe PIP-S based on phenanthroimidazole is designed and synthesized, which can be supported on SNP1 and SNP2 to improve their water solubility. UV-Vis and fluorescence spectroscopy are employed to investigate the specific recognition of Hg2+ by PIP-S. The detection limit (LOD) of PIP-S toward Hg2+ is determined to be 1.32 nmol·L-1 in DMF. The detection limits of PIP-S supported on SNP1 and SNP2 for Hg2+ in aqueous solution are 8.37 nmol·L-1 and 14.75 nmol·L-1, respectively. These results showed that PIP-S supported on SNP1 and SNP2 can detect Hg2+ with good selectivity and high sensitivity, and without the interference of other metal ions.
    Synthesis of Naphthol-based Phenolic Resins and Its Application in Lift-off Photoresist
    SUN Xiaoxia, SI Shuwei, ZHENG Xiangfei, LIU Jingcheng, MU Qidao
    2020, 38(4):  609-614.  DOI: 10.7517/issn.1674-0475.200306
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    Naphthol phenolic resins NAPR were synthesized through condensation of α-naphthol, m-cresol and formaldehyde, and the free phenolic hydroxyl groups of the resins were modified with BOC groups. FT-IR, 1H NMR, GPC, and TGA were used to characterize the structure and properties of the resins. Lift-off photoresist was prepared with NAPR-BOC-2 as matrix resin.The resolution, morphology and heat resistance of photoresist were tested, and the maximum resolution of the photoresist was 0.6 μm, and the heat resistance was up to 130℃.
    Preparation of the Photosensitive Amphiphilic Compound Having an Azobenzene Group and the Effect of the Light Illumination on Its Properties
    CHAO Junjie, JIANG Xiaoming
    2020, 38(4):  615-620.  DOI: 10.7517/issn.1674-0475.200402
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    A photosensitive amphiphilic compound (AS), which has an azobenzene group, was synthesized using p-methylaniline and phenol as the start material in four steps. Its structure was characterized by 1H NMR. The photoisomerization of the compound was studied by ultraviolet absorption spectroscopy. The results show that the structure of AS is changed from the trans-conformation to the cis-conformation after UV irradiation. The surface tension of AS was measured in the aqueous solution and the corresponding physicochemical parameters were calculated. The results show that after UV irradiation the values of cmc and γcmc increase,Гmax decreases, and Amin increases. The contact angle of the AS solution was measured on the quartz surface. The results show that the contact angle decreases after UV irradiation, and the wetting properties of AS is increased on the quartz surface. The adsorption process of AS was studied on the quartz surface by QCM-D. The results show that the amphiphilic molecule can adsorb onto the quartz surface to form a rigid film. After UV irradiation, the adsorption mass of AS is decreased on the quartz surface and the thickness of the adsorption film is decreased.
    Model Analysis of Fetal Intrauterine Hypoxia Predicted by Color Doppler Ultrasound Parameters MCA and UA Combined with Fetal Heart Rate Monitoring
    QIU Mengmeng, LI Gonglu
    2020, 38(4):  621-625.  DOI: 10.7517/issn.1674-0475.191101
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    In this paper, the predictive value of the middle cerebral artery (MCA) and umbilical artery (UA) combined with fetal heart monitoring for intrauterine hypoxia were investigated. A total of 400 pregnant women were selected. The patients were divided into case group (72 cases) and control group (328 cases) according to with or without intrauterine hypoxia. The ratio of MCA to UA resistance index (MCA/UA), including RI, PI, and the ratio of systolic peak velocity to end-diastolic flow velocity (S/D), were compared between the two groups to analyze the evaluating effect of the parameters on intrauterine hypoxia. The RI, PI and S/D of MCA in the case group were smaller than that in the control group, while the RI, PI and S/D of UA were higher than that in the control group, and the data of MCA/UA in the case group were lower than that in the control group (P<0.05). Fetal heart monitoring indicated that the abnormal rate of fetal heart in the case group was significantly higher than that in the control group (P<0.05). The ROC curve indicated that the area under the curve predicted by RI, PI and S/D of MCA/UA was 0.628, 0.661 and 0.598, respectively. The consistency between fetal cardiac monitoring and clinical diagnosis on intrauterine hypoxia was 0.661, while the consistency between color Doppler ultrasound combined with fetal cardiac monitoring and clinical diagnosis was 0.798. In conclusion, the use of color Doppler ultrasound parameters of MCA, UA and fetal heart monitoring in the prediction of intrauterine hypoxia can improve the accuracy of evaluation and facilitate early treatment.
    Evaluation of Left Ventricular Remodeling with Spot Tracking Echocardiography after PCI in Acute Myocardial Infarction Patients
    LI Sheng, ZHENG Guangmei
    2020, 38(4):  626-631.  DOI: 10.7517/issn.1674-0475.191111
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    This paper discussed the effect of spot tracking echocardiography on left ventricular remodeling (LVR) after percutaneous coronary intervention(PCI) in acute myocardial infarction(AMI) patients. 96 patients with AMI undergoing emergency PCI were selected and divided into LVR group and non-LVR group, and spot tracking echocardiographic parameters of 24 h and 6 months after PCI were collected. It is found that the rate of LVR after PCI in all patients was 35.42%. Compared with the postoperative parameters of 24 h after PCI, LVESV and LVEDV in LVR group after PCI for 6 months increased but LVEF decreased significantly, while LVEF in non-LVR group after PCI for 6 months was higher significantly (P<0.05). LVESV, LVEDV and LVEF after PCI for 6 months of the two groups had significant differences (P<0.05). Compared with non-LVR group, left ventricular GLS, GRS and GCS in LVR group were lower significantly, left ventricular longitudinal and radial Ts-SD were higher significantly (P<0.05). Multivariate logistic analysis showed that GLS, GRS and GCS were independent predictors of LVR after PCI in AMI patients. ROC curve analysis showed that AUC were gradually decreased as GLS>GCS>GRS. In a word, GLS, GCS and GRS examined by spot tracking echocardiography can objectively predict LVR risk after PCI in AMI patients, and GLS is the most significant predictor.
    The Value of Transcranial Color Code Sonography Blood Flow Parameters in the Diagnosis of Carotid Stenosis in Patients with Transient Ischemic Attack
    ZHAI Jiangyu, LU Qingwei
    2020, 38(4):  632-636.  DOI: 10.7517/issn.1674-0475.191202
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    To investigate the value of transcranial color code sonography (TCCS) blood flow parameters in the diagnosis of carotid stenosis in patients with transient ischemic attack (TIA). TIA patients were selected as the study group and healthy people in the same period were selected as the control group. Both groups were given DSA examination and TCCS examination.DSA examination results were used as the gold standard to analyze the diagnostic efficiency of TCCS blood flow parameters on carotid stenosis. The results showed that the PSV, EDV, MFV, PI and RI of the positive side of carotid stenosis in the study group were all higher than those of the negative side and the control group (P<0.05). ROC curve analysis results showed that, the best cut-off points of TCCS blood flow parameters in the diagnosis of mild, moderate and severe carotid stenosis were PSV ≥ 110 cm/s or MFV ≥ 65 cm/s, PSV ≥ 145 cm/s or MFV ≥ 85 cm/s, PSV ≥ 190 cm/s or MFV ≥ 115 cm/s, respectively. The coincidence rate of the best cut-off points of TCCS blood flow parameters in the diagnosis of mild, moderate and severe carotid stenosis was good agreement with DSA (Kappa=0.875, P=0.000). Therefore, TCCS blood flow parameters can effectively monitor the hemodynamic changes in patients with TIA, and have high diagnostic value for carotid stenosis.
    The Value of Multi-slice Spiral CT Combined with Biochemical Index in the Diagnosis of Acute Pancreatitis
    HUANG Jingyu, LIU Hongshu
    2020, 38(4):  637-641.  DOI: 10.7517/issn.1674-0475.191206
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    To investigate the value of multi-slice spiral CT (MSCT) combined with serum amylase (SAMY), urine amylase (UAMY) and lipase (LPS) in the diagnosis of acute pancreatitis. 80 patients with acute pancreatitis were selected as the observation group, and 80 healthy persons in the same period were selected as the control group, in this study. All patients were given MSCT plain scan and dynamic enhanced scan, and the levels of SAMY, UAMY and LPS were detected. To observe the MSCT imaging of acute pancreatitis. To compare the levels of SAMY, UAMY and LPS in the two groups. To compare the sensitivity and specificity of different examination methods in the diagnosis of acute pancreatitis. The results showed that the MSCT imaging features of acute pancreatitis are characteristic, in which the dynamic enhanced scan of acute edematous pancreatitis shows homogeneous enhancement, and the dynamic enhanced scan of acute necrotic pancreatitis shows uneven enhancement. The levels of SAMY, UAMY and LPS in the observation group were significantly higher than those in the control group (P<0.05). The sensitivity and specificity of MSCT combined with SAMY, UAMY and LPS in the diagnosis of acute pancreatitis were significantly higher than those of single and multiple combined examinations (P<0.05). Therefore, MSCT is helpful for the early qualitative diagnosis of acute pancreatitis, and combined with biochemical index can improve the sensitivity and specificity in the diagnosis of acute pancreatitis, which has important clinical application value.
    Research on the Effect of Color Doppler Elastography in the Diagnosis of Thyroid Carcinoma
    XU Juyong, LIU Zhen, LI Zhijun, LYU Shasha
    2020, 38(4):  642-646.  DOI: 10.7517/issn.1674-0475.191209
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    The effects of different diagnostic methods in the diagnosis of thyroid cancer were investigated in this study. A total of 126 thyroid cancer patients were selected, and performed the thyroid color Doppler elastography and ordinary color Doppler ultrasound. The results showed that the diagnostic accuracy of color Doppler elastography was higher than that of ordinary color Doppler ultrasound. The malignant proportion detected by color Doppler elastography were 77.38%, which was significantly higher than 44.64% of ordinary Doppler ultrasound (P<0.05). The malignant signs of patients with thyroid cancer were more than 80% of all malignant signs, and hypoechoic mass was the most sign in the proportion of malignant signs in patients with thyroid cancer, accounting for 71.43%. Logistics regression analysis showed that the influencing factors for the diagnosis of thyroid cancer were lymph node metastasis and pathological type. This study shows that the use of thyroid color Doppler elastography can effectively improve the diagnostic accuracy of malignant thyroid lesions, and can also effectively show the benign and malignant lesion, providing a new and reliable method for clinical diagnosis.
    The Correlation Between Ultrasound Features and Cervical Lymph Node Metastasis of Thyroid Cancer
    LIU Songyu, WU Fangfang, XU Shanshan
    2020, 38(4):  647-651.  DOI: 10.7517/issn.1674-0475.191213
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    This article discusses the correlation between ultrasound features and cervical lymph node metastasis (CLNM) of thyroid cancer (TC). 110 patients with TC were enrolled. According to pathological results, they were divided into metastasis group (59 cases) and non-metastasis group (51 cases). Both groups were completed the two-dimensional ultrasound and color Doppler ultrasound examination before the operation. Pearson correlation coefficient and Logistic analysis were used to get the correlation between ultrasound features and CLNM of TC. The results show that, the cases in metastasis group with ultrasound features as nodule diameter ≥ 1.5 cm, aspect ratio ≥ 1, inhomogeneous echo, microcalcification, abundant internal blood supply and the distance from capsule (d)=0 were more than those in the non-metastasis group (P<0.05). Pearson analysis showed a significant positive correlation between CLNM and nodule diameter, aspect ratio, echo, microcalcification and abundant internal blood supply (P<0.05). Logistic analysis showed these ultrasound features such as nodule diameter ≥ 1.5 cm, aspect ratio ≥ 1, inhomogeneous echo, microcalcification, abundant internal blood supply and distance from capsule (d)=0 were independent risk factors of CLNM (P<0.05).
    Effect of Ultrasound Combined with CT Guided Percutaneous Biopsy on Diagnosis of Peripheral Lung Cancer
    ZHOU Pinghui, ZHAO Zhiqiang, YANG Jing, YANG Jinhua
    2020, 38(4):  652-656.  DOI: 10.7517/issn.1674-0475.191214
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    In order to explore the clinical value of percutaneous biopsy guided by ultrasound combined with CT for the diagnosis of peripheral lung cancer, the effects of CT, ultrasound and combined guided percutaneous biopsy in the patients were compared. The results showed that the accuracy of benign and malignant tumors percutaneous biopsy guided by CT combined with ultrasound was significantly higher than that of ultrasound or CT alone (P<0.05). In malignant tumors, the accuracy rate is 100% for squamous cell carcinoma, small cell lung cancer, poorly differentiated cancer, large cell carcinoma, adenosquamous carcinoma, metastatic cancer, and indefinite cancer; in benign lesions, lung abscess and tissue pneumonia, pulmonary aspergillosis, pneumonia, and granuloma were all 100% accurate. Compared with CT-guided puncture, the incidence of percutaneous pneumothorax under CT and ultrasound guidance was significantly reduced (P<0.05).Compared with ultrasound-guided puncture, the incidence of percutaneous pneumothorax and hemoptysis under CT and ultrasound guidance was significantly reduced (P<0.05). In conclusion, CT combined with ultrasound-guided percutaneous puncture is a sensitive tool for the diagnosis of peripheral lung cancer. It can accurately obtain materials and improve the diagnostic accuracy of patients.
    Diagnostic Effect of Transabdominal Ultrasound Combined with Magnetic Resonance Imaging on Pernicious Placenta Previa and Pregnancy Outcome
    HAN Yuwen, ZHENG Yanli, CHEN Liping, LU Xiaoyan, HAN Yun, YOU Jun, ZHANG Zhongxin
    2020, 38(4):  657-661.  DOI: 10.7517/issn.1674-0475.191215
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    The diagnostic effects of transabdominal ultrasound combined with magnetic resonance imaging (MRI) on patients of pernicious placenta previa were analyzed in this study. 270 patients with PPP were selected as subjects. The effects of transabdominal ultrasound, MRI and the combined diagnosis were compared. The detection rate of combined group was significantly higher than that of transabdominal ultrasound group and MRI group (P<0.05). The coincidence rate and overall accuracy of the combined diagnosis were higher than those of the ultrasound and MRI groups. There were significant differences in the delivery methods of the groups (P<0.05), but there were no significant differences in the surgical treatment methods and the amount of blood transfusion (P>0.05). Compared with the ultrasound group and the MRI group, the incidence rates of hematorrhea and shock in the combined group was significantly different (P<0.05), but the rates of premature delivery and neonatal asphyxia were lower in the combined group than in the other groups (P>0.05). In conclusion, transabdominal ultrasound combined with MRI can improve the detection rate of PPP and improve pregnancy outcome.
    Accuracy of Cone Beam Computed Tomography in Assessing the Therapeutic Effects of Er: YAG Laser with Guided Tissue Regeneration on Furcation Involvements of Mandibular Molars
    WANG Jinhe
    2020, 38(4):  662-665.  DOI: 10.7517/issn.1674-0475.191217
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    In this paper, we discussed the effect of cone beam CT in assessing the therapeutic effects of Er:YAG laser with guided tissue regeneration (GTR)on furcation involvements of mandibular molars. 30 patients with furcation involvement of mandibular molars (degree Ⅱ) were divided randomly into group C (treated with GTR alone) and group L (treated with Er:YAG laser combined with GTR). Sulus bleeding index (SBI), gingival recession (GR), keratinized gingival (KG), probing pocket depth (PPD), horizontal clinical attachment loss (CAL-H), vertical clinical attachment loss(CAL-V) and cone beam CT measurement indexes such as vertical bone loss (BL-V), horizontal bone loss (BL-H) were observed and compared between the two groups. The results showed that SBI decreased and GR increased in both groups (P<0.05) one year after surgery. PPD, CAL-H and CAL-V decreased in both groups (P<0.05),the changes of group L were greater than those of group C (P<0.05). There were no statistical differences in the pre-operative conical beam CT measurement indexes such as BL-V and BL-H in the two groups (P>0.05). BL-V and BL-H improved one year after operation in both groups (P<0.05), and there were statistical differences in the improvements between the two groups (P<0.05). The results indicate that Er:YAG laser combined with GTR is better than GTR alone in the treatment of furcation involvements of mandibular molars. Cone beam CT has certain application value in assessing the therapeutic effects of Er:YAG laser combined with GTR in the treatment of furcation defect.
    The Application Value of High Frequency Color Doppler Ultrasound in the Early Diagnosis and the Evaluation of Acupuncture Effect of Knee Synovitis
    LIU Liqin, WANG Aicheng, LIU Chunyan, QIN Zhenlong, TIAN Xiangdong
    2020, 38(4):  666-670.  DOI: 10.7517/issn.1674-0475.191218
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    To investigate the application value of high frequency color Doppler ultrasound in the early diagnosis and the evaluation of acupuncture effect of knee synovitis. 86 patients with knee synovitis were examined by high-frequency color Doppler ultrasound, to observe the high frequency color Doppler ultrasound manifestations of synovium, joint cavity effusion and articular cartilage. Reexamined the high frequency color Doppler ultrasound, after acupuncture treatment for 2 and 4 weeks. To compared the synovium thickness of knee joint, the improvement of effusion in joint cavity, VAS and LKSS scores, before and after treatment. The results showed that, synovium thickening, joint effusion and cartilage lesions existed in different degrees in all patients.After 2 weeks of treatment, the synovium thickness, joint cavity effusion and VAS scores of the patients were lower than before treatment, LKSS scores were higher than before treatment, and the above indexes after 4 weeks of treatment were better than after 2 weeks of treatment, the difference was statistically significant (P<0.05). High frequency color Doppler ultrasound can clearly show the types of lesions such as knee synovium thickening, joint cavity effusion and cartilage lesions. It has important clinical value for the early diagnosis of knee synovitis and the evaluation of acupuncture effect.
    Efficacy Analysis of Endovascular Stenting in Elderly Patients with Symptomatic Vertebral Artery Stenosis
    CHEN Shangxiong, TANG Jie, DU Song, ZHANG Hui, SUN Long, LIU Ping, MOU Wei, HAO Yingxue
    2020, 38(4):  671-675.  DOI: 10.7517/issn.1674-0475.191219
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    In this paper, we analyzed the clinical efficacy of endovascular stenting for symptomatic vertebral artery stenosis in elderly patients. A total of 42 aged patients who were diagnosed as symptomatic vertebral artery stenosis were randomly chosen. According to the different methods of treatment, they were divided into two groups:patients who were treated with endovascular stent angioplasty as the experimental group; the other patients as the control group. The patients' recovery time, length of stay, transcranial doppler ultrasound hemodynamic index and the occurrence of adverse cardiovascular events were compared between the two groups. All elderly patients with symptomatic vertebral artery stenosis were followed up for one year to record their prognosis. The results showed that the recovery time and length of hospital stay of elderly patients treated by stent angioplasty were significantly shorter than that of the control group. The change of hemodynamics indexes of the experimental group were better than those in the control group. The incidence of adverse cardiovascular events and prognosis in the experimental group was significantly less than those in the control group. According to above multiple indicators, endovascular stenting has a competitively good effect on symptomatic vertebral artery stenosis in the elderly, and should be used more comprehensively as a new reliable clinical treatment.
    The Diagnostic Efficacy of Lung Ultrasound Combined with Serum PCT and CRP on the Community Acquired Pneumonia in Children
    LI Yu, YIN Xiao
    2020, 38(4):  676-680.  DOI: 10.7517/issn.1674-0475.191221
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    The efficacy of lung ultrasound (LUS) combined with serum procalcitonin (PCT) and C-reactive protein (CRP) in the diagnosis of community acquired pneumonia (CAP) in children is analyzed in this study. 176 children with CAP from February 2017 to November 2019 were selected and examined by chest CT, as well as the serum PCT and CRP. The results of the chest CT were the diagnostic criteria, the children were divided into CAP group (102 cases) and N-CAP group (74 cases). The LUS characteristics and the levels of serum PCT, CRP were compared. The diagnostic efficacy of LUS combined with PCT and CRP was analyzed by ROC curve. The results showed that, the pulmonary interstitial syndrome, pulmonary consolidation, abnormal pleura line, bronchus syndrome, pleural effusion and the levels of serum PCT, CRP of CAP group were higher than those of the N-CAP group, and the difference was statistically significant (P<0.05). The AUC, sensitivity and specificity of LUS combined with PCT and CRP in the diagnosis of CAP in children were higher than those of the single examination (P<0.05). Therefore, LUS combined with PCT and CRP can improve the diagnostic efficacy of CAP in children.
    About the Status and Prospects of LI-RADS for Children
    ZHANG Peng, WANG Zhipeng, LI Jingwei, GAO Fengguo, CHEN Yajing, WANG Peng
    2020, 38(4):  681-683.  DOI: 10.7517/issn.1674-0475.191222
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    The Liver Imaging Reporting and Data System (LI-RADS) provides a basis for imaging diagnosis and postoperative evaluation of adult patients with hepatocellular carcinoma. The system uses imaging features to evaluate and classify liver tumors and cell survival after tumor surgery. The LI-RADS for children include a variety of imaging diagnostics, imaging technology, imaging equipment, including ultrasound, contrast ultrasound, CT, MRI, etc. The system has two main functions, one is to provide the best choice of imaging methods for children,the other is to provide guidance on specific clinical and imaging protocols for known or suspected liver tumors. The system will benefit from physicians involved in the diagnosis and treatment of childhood liver disease, It is helpful to improve the image quality of children, reduce the error of image analysis, enhance imaging communication, and improve the level of diagnosis and treatment.
    Comparative Study on MR Characteristics and Risk Factors between Young Patients and Middle-aged and elderly Patients with Acute Ischemic Stroke and the Value of Prevention
    WEI Julin, ZHAO Zhixiong
    2020, 38(4):  684-689.  DOI: 10.7517/issn.1674-0475.191224
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    In this paper, the is risk factors and MR characteristics of acute cerebral infarction in young and middle-aged and elderly were studied, and it is value in clinical diagnosis, treatment and prevention was discussed. To compare and analyze the medical records and imaging data of the young group and the middle-aged and elderly group.The results showed that the most common risk factors were hypertension, hypertriglyceridemia and smoking. The incidence of hypertension, diabetes and hypercholesterolemia in the middle-aged and elderly patients with acute cerebral infarction was significantly higher than that in the young group (P<0.05); the incidence of hypertriglyceridemia and smoking in the young group was significantly higher middle-aged and elderly group (P<0.05). The difference between the two groups was statistically significant in the normal rate of brain MRA and the abnormal rate of multiple vessels (P<0.05); there was no statistical difference in lesion size and number of lesions, and between various parts of acute cerebral infarction (P>0.05).
    Clinical Value of Venography-guided PICC Catheterization Assisted by Continuous Radiography
    WANG Xiuqing, WANG Xiaoyan, WANG Chunhong, LIU Xiaofang
    2020, 38(4):  690-693.  DOI: 10.7517/issn.1674-0475.191226
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    The purpose of this study was to analyze the clinical effects of peripherally inserted central catheter (PICC) catheterization in our hospital with the guidance of venography and continuous radiography. All selected cases were divided into experimental group and control group according to the random number table method(the control group received PICC catheterization in the conventional way). The success rate and complications of PICC catheterization were compared between the two groups of patients. The results showed that the one-time success rate of PICC catheterization was 100% in experimental group and 90% in control group. The incidence of venous thrombosis, phlebitis, and catheter ectopic in experimental group was 0%, and the incidence of local skin infection was 2.00%. The incidence of venous thrombosis in control group was 2.00%, and the incidence of phlebitis was 6.00%, The incidence of local skin infections was 10.00%, the incidence of ectopic catheter prolapse was 6.00%, and the total incidence of complications was 24%. The incidence of postoperative complications was significantly lower in experimental group than in control group (P<0.05). In summary, PICC catheterization under the guidance of venography and continuous X-ray fluoroscopy can effectively improve the success rate of PICC catheterization in patients, and can prevent and solve the complications of PICC catheterization in time and effectively.
    Diagnostic Effect of Color Doppler Ultrasound Combined with Magnetic Resonance Imaging for Ovarian Tumor
    HAN Lingfeng, ZHAO Jun
    2020, 38(4):  694-697.  DOI: 10.7517/issn.1674-0475.191227
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    The application value of color Doppler ultrasound combined with magnetic resonance imaging (MRI) in the diagnosis of ovarian tumors is analyzed in this study. 64 patients with ovarian tumors were enrolled. Color Doppler ultrasound, MRI and the combined examination were performed with informed consent. The results of the operation were the diagnostic criteria, and the difference between three methods were compared. The sensitivity, specificity and accuracy of the color Doppler ultrasound combined with MRI was higher than that of Color Doppler ultrasound and MRI, and the difference was statistically significant (P<0.05). According to this, in the clinical diagnosis of ovarian tumors, the sensitivity, specificity and accuracy of Color Doppler ultrasound combined with MRI are at a high level.
    Application of Color Doppler Ultrasonography in Screening of Hip Joint Development in Newborns with Multiple High Risk Factors
    ZHANG Xia, KONG Heye, WANG Lichun
    2020, 38(4):  698-702.  DOI: 10.7517/issn.1674-0475.191228
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    115 cases of newborns who were screened for hip development due to multiple high-risk factors of DDH were selected as the study group. Another 100 cases of normal newborns who underwent child health checkup in our hospital during the same period were selected as the control group. To observe the color Doppler ultrasound of the two groups of newborns to check the α and β angles of the hip joint, and analyze the results of color Doppler ultrasound screening by Graf hip pathology typing. The color Doppler Graf method found that the α angle of hip joints of newborns in the study group was significantly lower than that of the control group, but the β angle of hip joints was significantly higher than that in the control group (P<0.05).This paper concludes that, the color doppler ultrasound has high application value in the screening of hip joint development in newborns with multiple high-risk factors of DDH, can accurately evaluate the type of DDH, and can show the differences in neonatal DDH among different high-risk factors of DDH.It can provide effective diagnosis and treatment for newborns as early as possible.
    Effects of Er: YAG Laser Combined with Budesonide on Male OSAHS
    WANG Yanhui, LIANG Suozhu, WANG Jianshuang, YIN Huili
    2020, 38(4):  703-707.  DOI: 10.7517/issn.1674-0475.200105
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    This paper intends to investigate the effect of Er:YAG laser combined with Budesonide spray on male obstructive sleep apnea hypopnea syndrome(OSAHS). 90 male patients with OSAHS were randomly divided into control group (Budesonide spray treatment, n=45) and observation group (Er:YAG laser combined with Budesonide spray treatment, n=45). The differences in apnea hypopnea index (AHI), apnea time, the lowest nighttime SpO2 and interleukin-6 (IL-6), tumor necrosis factor -α(TNF-α), nuclear factor κB (NF-κB), alveolar surface active protein-A (SP-A), alveolar surface active protein-D (SP-D), total testosterone(TT), luteinizing hormone (LH), follicle stimulating hormone (FSH)were compared between the two groups before and after treatment. The results showed that the total effective rate in the observation group was significantly higher than that in the control group (P<0.05). Compared with those before treatment, the AHI, maximum apnea time, the serum levels of IL-6,TNF-α, NF-κB, SP-A, SP-D in two groups were significantly decreased after treatment (P<0.05), while the lowest nighttime SpO2, the serum levels of TT, LH and FSH in two groups increased significantly (P<0.05). The improvement in the observation group was better than that in the control group (P< 0.05). The results indicate that Er:YAG laser combined with Budesonide spray is more effective than Budesonide spray alone in the treatment of mild OSAHS, which can not only improve the clinical symptoms, but also conduce to recovery of sex hormones and improvement of inflammatory response of the patients.
    Retrospective Analysis of Contrast-Enhanced Ultrasound Findings of Hepatic Malignancies of Different Pathological Types
    WANG Qin, WANG Jinping, WANG Jiajia, LI Baoqi
    2020, 38(4):  708-712.  DOI: 10.7517/issn.1674-0475.200106
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    The purpose of this article is to explore the value of contrast-enhanced ultrasound (CEUS) in differential diagnosis of hepatic malignancies of different pathological types. CEUS findings of 38 cases of hepatic malignancies confirmed by pathology were analyzed retrospectively and compared with histopathological results. There were 12 cases of Hepatocellular carcinoma (HCC), 8 cases of intrahepatic cholangiocarcinoma (ICC) and 18 cases of metastatic liver cancer (MLC) in 38 patients, of whom CEUS almost showed perfusion characteristics of "fast in and fast out". In the arterial phase:HCC showed rapid total hyper-enhancement; ICC showed uneven and high enhancement (75.0%), and some showed a "spoke sign" (50%); MLC showed total hyper-enhancement (55.6%) or thick rim-like hyper-enhancement (44.4%). In the portal phase and delayed phase:Rapid regression presented hypo-enhancement (89.5%) or non-enhancement (7.9%). There were differences in the time of enhancement, peak and regression in different tumors (P<0.001). According to the order from fast to slow, they were MLC, ICC, and HCC respectively.In summary, most hepatic malignancies have certain characteristic manifestations in contrast-enhanced ultrasound and are of great value in differential diagnosis.
    Comparative Analysis of Diagnostic Accuracy of CT Multiplanar 3D Reconstruction Technology and MRI Scanning for Lumbar Disc Herniation
    LI Xuehong, TONG Hengbo, LIU Min
    2020, 38(4):  713-717.  DOI: 10.7517/issn.1674-0475.200108
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    The comparative analysis of diagnostic accuracy of computerized tomography (CT) multiplanar 3D reconstruction (MPR) technology and magnetic resonance imaging (MRI) scanning for lumbar disc herniation (LDH) in this study.120 patients with LDH were selected as the subjects of this study. According to the random number table method, 120 patients were divided into group CT and group MRI, 60 cases in each group, group CT was given CT-MPR scan, MRI group was given MRI scan, and the operation pathology was compared, the diagnosis of LDH was compared in the two groups. The results showed that the detection rates of the location, degree, Schmod nodule of disc herniation and nerve root compression, dural sac compression, and vacuum phenomenon in group CT and group MRI were basically the same (P>0.05). The diagnostic accuracy to LDH of CT and MRI groups were 96.67% and 100% respectively (P>0.05). This study confirms that, CT-MPR and MRI can effectively evaluate the degree, location and condition of LDH disc herniation, and it has a good diagnostic accuracy.
    Effect of MSCT Perfusion Imaging Parameters on Differential Diagnosis of Pancreatic Cancer and Their Relationship with Malignant Biological Behavior of Tumor and Microvessel Density
    FU Deli, DU Xinyue, LI Mingshan
    2020, 38(4):  718-723.  DOI: 10.7517/issn.1674-0475.200112
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    In this paper, 68 patients with pancreatic cancer were selected as the pancreatic cancer group,and 68 patients with acute pancreatitis who underwent surgery during the same period were selected as the pancreatitis group,the effects of multi-slice spiral CT (MSCT) perfusion imaging parameters on the differential diagnosis of pancreatic cancer and their relationship with malignant biological behavior of tumor and microvessel density were investigated. The results showed that MSCT perfusion imaging parameters have certain clinical value for the differential diagnosis of pancreatic cancer,the values of BV,BF,PS,and MTT parameters are closely related to tumor invasion genes,proliferation genes,and microvascular density values,which can provide theoretical basis for clinical condition and prognosis evaluation.
    Analysis of the Application Value and Detection Rate of Upper Gastrointestinal Angiography and CT Scan in the Diagnosis of Gastric Tumors
    LU Wei, HE Shunli
    2020, 38(4):  724-728.  DOI: 10.7517/issn.1674-0475.200202
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    To investigate the application value and detection rate of upper gastrointestinal angiography and CT scan in the diagnosis of gastric tumors. All patients underwent CT scan and upper gastrointestinal angiography, and took the clinical/gastroscopy results as the gold standard. Compared with the gold standard, there was no significant difference in the accuracy, specificity and sensitivity of CT scan and upper gastrointestinal angiography (P>0.05).Both upper gastrointestinal angiography and CT scan can effectively diagnose gastric tumors. However, for larger lesions, CT scan is more advantageous, and small for the lesions, the advantages of the upper gastrointestinal angiography are more obvious. When the lesions invade the muscular layer and submucosa, the upper gastrointestinal angiography is more sensitive. The combination of the two is the most ideal for clinical application value.
    The Diagnostic Effect of 64-slice Spiral CT Angiography in Aneurysmal Subarachnoid Hemorrhage
    WEN Jianchun, ZHANG Xing
    2020, 38(4):  729-733.  DOI: 10.7517/issn.1674-0475.200205
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    In order to explore the diagnostic effect of 64-slice spiral CT angiography in aneurysmal subarachnoid hemorrhage, 152 cases of patients with aneurysms were performed with 64 row spiral CT cerebral angiography and digital subtraction angiography. We analyzed the results of 64 row spiral CT cerebral angiography on the diagnosis of aneurysmal subarachnoid hemorrhage, and evaluated its diagnostic sensitivity, specificity and accuracy. The clinical data showed that there was no significant difference between 64-slice spiral CT angiography and digital subtraction angiography in their diagnostic sensitivity, specificity, accuracy, positive predictive value and negative predictive value in patients with aneurysmal subarachnoid hemorrhage (P>0.05). In addition, the results of 64-slice spiral CT cerebral angiography showed no significant difference with the aneurysm data measured during surgery (P>0.05). Moreover, 64-slice spiral CT angiography showed better aneurysm details than digital subtraction angiography (P<0.05). It was indicated that 64-slice spiral CT angiography has a good application value for the diagnosis of aneurysmal subarachnoid hemorrhage, and can better display the details of patients' aneurysms, which is helpful for guiding the development of surgical plans for brain aneurysms and suitable for clinical promotion.
    The Relationship between Enhanced CT and Clinicopathological Characteristics and Prognosis of Non-small Cell Lung Cancer
    WU Tao, CHEN Jiang
    2020, 38(4):  734-738.  DOI: 10.7517/issn.1674-0475.200206
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    In this study,the relationship between enhanced CT parameters and clinicpathological characteristics of non-small cell lung cancer was analyzed,and the factors influencing the prognosis were discussed. The results showed that tumor size, CT enhancement, number of lymph node enlargement, and lymph node size were related to the degree of non-small cell lung cancer differentiation, TNM staging, and lymph node metastasis. The large tumor size, lymphadenopathy, tumor CT enhancement, and lymph node metastasis are associated with poor prognosis,and are independent risk factors for prognosis. It indicates that enhanced CT parameters are correlated with the clinicopathological characteristics of patients with non-small cell lung cancer and can predict the prognosis of patients with non-small cell lung cancer.
    Diagnostic Value of 12-lead Dynamic Electrocardiogram Combined with CT Angiography in Asymptomatic Myocardial Ischemia
    LIAO Pinliang, LI Hailing, ZHANG Zhihui, QU Xiaolong, ZHUANG Guoqiang, MA Yuanqiuzi
    2020, 38(4):  739-743.  DOI: 10.7517/issn.1674-0475.200207
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    A total of 98 patients with suspected asymptomatic myocardial ischemia (SMI) were enrolled. All patients underwent 12-lead dynamic electrocardiography and computed tomography coronary angiography (CTA). The degree of coronary stenosis and the status of asymptomatic myocardial ischemia were analyzed. Based on the results of coronary angiography (CAG), the accuracy, sensitivity, and specificity of 12-lead dynamic electrocardiogram, CTA, and the combination of two methods were compared. The sensitivity and accuracy of CTA were significantly higher than that of 12-lead dynamic electrocardiogram (P<0.05). The sensitivity and specificity of the combined examination were significantly higher than those of CTA or dynamic electrocardiogram alone (P<0.05). Above results show that the combined application of 12-lead dynamic electrocardiogram and CTA have significant value in the diagnosis of SMI. They can be widely used in clinical practice, and provide a practical reference for the diagnosis and evaluation of SMI.
    Changes of Echocardiography and Pulmonary Function Indexes in Children with Wheezing Diseases and Their Clinical Significance
    YUAN Yuan, ZHAO Jing, CAI Xiaoyan
    2020, 38(4):  744-747.  DOI: 10.7517/issn.1674-0475.200316
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    To analyze the changes of echocardiogram and pulmonary function indexes in children with wheezing diseases and their clinical significance. Children with wheezing diseases were taken as the observation group and healthy children at the same time as the control group. After admission, the two groups were examined by echocardiography and lung function. The basic data, echocardiogram and lung function tests were compared between the two groups. There was no significant difference in the data of the basic data items such as gender, age, height and body weight between the two groups (P>0.05). The pulmonary systolic pressure and the maximum reflux velocity index of the tricuspid valve in the observation group were higher than those in the control group (P<0.05). The kilogram tidal volume, peak time ratio and peak volume ratio were lower than that in the control group (P<0.05). Echocardiography and pulmonary function indexes can provide a reference for the clinical diagnosis of children with wheezing disease, and help to formulate subsequent treatment plans, which has clinical value.
    The Value of Fibroscan Combined with Blood NLR and PDW in Predicting the Prognosis of Liver Cirrhosis Caused by Chronic HBV Infection and Its Relationship with Liver Function
    ZHAO Conglin, LI Shuyi, ZHANG Yanjun
    2020, 38(4):  748-752.  DOI: 10.7517/issn.1674.0475.200325
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    In this paper, we analyzed the predictive value of FibroScan combined with blood NLR and PDW on the prognosis of liver cirrhosis caused by chronic HBV infection and its relationship with liver function. We selected 86 patients with chronic HBV infection-related cirrhosis for retrospective analysis, and they were divided into the complication group (n=48) and the non-complication group (n=38) according to the prognosis of patients with or without cirrhotic complications. The hardness values of liver and spleen, levels of blood NLR/PDW, serum liver function indexes (AST, ALT, TBIL) of FibroScan in the two groups were measured and compared. The relationship between hardness values of liver and spleen, blood NLR/PDW levels and liver function of patients were explored, and the predictive value of liver and spleen hardness values, blood NLR/PDW on prognosis were observed. The results showed that the hardness values of liver and spleen, blood NLR/PDW and serum AST, ALT, TBIL levels in the complication group were higher than those in the non-complication group (P<0.05); the hardness values of liver and spleen, blood NLR/PDW levels were positively correlated with serum AST, ALT, TBIL levels of patients (P<0.05). The efficacy of hardness values of liver and spleen in predicting the prognosis of patients with complications were higher, as well as the blood MLR/PDW. The sensitivity of joint prediction was 83.33%, and the specificity was 81.58%. It can be seen that FibroScan combined with blood NLR/PDW has a higher value in predicting the prognosis of cirrhosis associated with chronic HBV infection, and is closely related to the liver function of patients.