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Table of Content

    15 November 2020, Volume 38 Issue 6
    Content
    2020, 38(6):  0-0. 
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    Review and Articles
    A Color Transfer Method based on Neighborhood-first Searching and Texture Similarity Matching
    ZHU Ming, JIAO Huimin, ZHAO Xingyun
    2020, 38(6):  935-940.  DOI: 10.7517/issn.1674-0475.200416
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    To address the problem of grayscale image colorization in the fields of film and television, medical imaging, animation, space exploration and so on, a color transferring algorithm based on neighborhood-first search and texture similarity matching is proposed. For a pixel to be colorized in target grayscale image, the method first finds its candidate matching pixels based on the neighborhood-first searching scheme. Then, we define the concept of the texture eigenvector to describe the texture similarity between two pixels, and determine the final matching pixel by calculating the matching error based on the distance between the eigenvectors of the candidate pixels and the target pixel. To address the problem of image distortion occurred after global matching, the present method conducts one or more swatch matching procedures for the distortion regions of the colorized image. In the five test cases of image colorization, the proposed algorithm has a reasonable color transfer effect. Moreover, for the image with complex color composition or semantic content, this paper verifies the effectiveness of swatch matching through a case, and analyzes the problems and shortcomings of swatch matching.
    Biomimetic Synthesis of Au QDs and the Application of Glucose Detection in Serum
    ZHU Tao, ZHANG Yan, DONG Lulu, GUO Pengyue, YANG Dongzhi
    2020, 38(6):  941-949.  DOI: 10.7517/issn.1674-0475.200514
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    In the research of new synthesis methods of non-toxic nanomaterials, biomimetic synthesis has attracted the attention of many researchers because of its obvious advantages over chemical synthesis. Herein gold quantum dots (Au QDs) were prepared in living cells driven by cell life metabolism. The characterization shows that the prepared gold Au QDs have cubic crystal structure, uniform size distribution and a diameter of about 20 nm. Cell experiments showed that the biocompatibility of Au QDs synthesized in cells was significantly higher than that of traditional chemical synthesis. Under certain conditions, the fluorescence of Au QDs can be quenched by glucose, and the fluorescence quenching efficiency of Au QDs shows a good linear relationship with glucose concentration, with a linear range of 7.85×10-6-2.5×10-4 mol/L and a detection limit of 3.1×10-8 mol/L. This method was applied to detect blood glucose concentration in diabetic rats, and the result was consistent with that of blood glucose meter. The prepared Au QDs have low cytotoxicity and potential detection ability, and can be used for the detection of small biological molecules.
    Label-free and Rapid Detection of ATP Based on Molybdenum Oxide Quantum Dots
    HUANG Haiqing, XIAO Saijin, YANG Guangzhaoyao, ZHAO Jiahui
    2020, 38(6):  950-955.  DOI: 10.7517/issn.1674-0475.200602
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    Molybdenum oxide quantum dots (MoOx QDs) with excellent fluorescence performance were synthesized using MoS2 and H2O2 as the raw materials by a one-pot method at the room temperature. Based on the fluorescence "off-on" mode, a new rapid fluorescence detection of ATP was constructed, in which MoOx QDs was a fluorescent probe and Cu2+ was a quencher. Under the optimized condition, pH 7.5, 0.051 mg/mL MoOx QDs and 50 mol/L Cu2+, the fluorescence at 520 nm was gradually enhanced with increasing ATP concentration in the range of 25-250 mol/L. The calibration curve was F=785.40+9.05c with the correlation coefficient of 0.993. The coexistence of BSA, Ni2+, Mn2+, Mg2+, Fe3+, Co2+ and Ca2+ has negligible effect on ATP detection. Therefore, the "off-on" detection platform shows rapid and stable for sensing for ATP.
    The Relationship Between FibroScan, Blood miR-21 Detection and the Degree of Liver Fibrosis in Patients with Hepatitis B Cirrhosis and the Predictive Value for Prognosis
    LI Hongjiang, HU Suling, HE Jiusheng, HE Fuliang, LIU Zhenxia
    2020, 38(6):  956-961.  DOI: 10.7517/issn.1674-0475.200503
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    To investigate the relationship between FibroScan, blood miR-21 detection and the degree of liver fibrosis in patients with hepatitis B cirrhosis (HBC) and the value in predicting prognosis, 92 patients with HBC were selected as the case group, and 92 patients with chronic hepatitis B were selected as the control group. The results showed that the hardness value of the spleen and the liver, the level of blood miR-21, and the degree of liver fibrosis in the case group were higher than those in the control group. The spleen/liver stiffness values and blood miR-21 levels were positively correlated with the degree of liver fibrosis in HBC patients. The sensitivity of corresponding combined prediction was 68.42%, and specificity was 97.26%. After controlling the patient's baseline data such as age, body mass and gender, spleen/liver stiffness values and blood miR-21 were still important risk factors for the death of HBC patients (P<0.05). In conclusion, it is suggested that FibroScan parameters and changes of blood miR-21 levels are closely related to the degree of liver fibrosis and are independent risk factors for patients' death. The combined detection can provide a reference for the prognosis of clinical evaluation from the macro and micro levels.
    The Diagnostic Efficacy of Echocardiography Combined with Serum Hcy and PCSK9 on Coronary Heart Disease and the Relationship with the Severity of the Disease
    XIAO Qingye, LI Peng
    2020, 38(6):  962-966.  DOI: 10.7517/issn.1674-0475.200505
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    In this study, 124 patients with coronary heart disease were selected as the study group, and 124 patients who were suspected and excluded coronary heart disease by coronary angiography were selected as the control group. Color Doppler echocardiography were carried out on both groups. It was found that the contrast filling rate (β) and the maximum number of microbubbles (A) in the study group were lower than those in the control group, while serum homocysteine (Hcy) and proprotein convertase subtilisin 9 (PCSK9) levels were higher than those in the control group (P<0.05). It was also found that β, A, serum Hcy, PCSK9 were important influencing factors of coronary heart disease. The combination of β, A, serum Hcy and PCSK9 showed good efficacy in the diagnosis of coronary heart disease. The number of coronary artery lesions and the degree of stenosis in patients with coronary heart disease were negatively correlated with β and A values, and positively correlated with serum Hcy and PCSK9 levels (P<0.05). Therefore, the authors believe that β, A combined serum Hcy and PCSK9 have high application value in the diagnosis of coronary heart disease. These indexes are important influencing factors for the occurrence of coronary heart disease, and have good linear relationship with the number of coronary artery lesions and the degree of stenosis.
    The Evaluating Effect of Color Doppler Ultrasound on the Maturity of Autogenous Arteriovenous Fistula
    WANG Hui, ZHOU Wenxiu
    2020, 38(6):  967-970.  DOI: 10.7517/issn.1674-0475.200507
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    The evaluating effect of color Doppler ultrasound(CDUS)in monitoring the changes of hemodynamic parameters before and after operation of autogenous arteriovenous fistula (AVF) is analyzed in this study. 94 patients with AVF were examined by CDUS. The PSV, EDV, RI, RAD, CVD, RVF and CVF at four time points were measured and compared:before operation, 2,4 and 8 weeks after operation. The results show that the means of PSV, EDV, RAD, CVD, RVF and CVF at 2,4 and 8 weeks after operation were significantly increased than those before operation (P<0.05). The mean of RI at 8 weeks later was significantly lower than that before operation (P<0.05). 81 cases of arteriovenous fistula were mature; the maturity was 86.17%. The PSV, EDV, RAD and RVF of mature group were significantly increased than those of immature group (P<0.05), while RI value was significantly lower than that of immature group (P<0.05). Therefore, CDUS can real-time monitor the dynamic changes of hemodynamic parameters and evaluate the maturity of AVF effectively.
    Predictive Value of Pelvic Floor Ultrasound Parameters Combined with Serum 25(OH)D Level on Postpartum Stress Urinary Incontinence and the Relationship with the State of Disease
    LI Liqiong, WANG Dan, HE Guannan, LI Ping, HU Xie
    2020, 38(6):  971-976.  DOI: 10.7517/issn.1674-0475.200511
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    120 patients with postpartum stress urinary incontinence (PSUI) were selected as the research group, and 120 non-PSUI women in the same period were selected as the control group. Pelvic floor ultrasound and laboratory tests found that the pelvic floor ultrasound parameters in the research group including urethral rotation angle (URA), bladder urethral posterior angle (PUVA), bladder neck mobility (BND) were higher than those of the control group, while serum 25-hydroxyvitamin D[25(OH)D] level was lower than that of the control group (P<0.05). The combined prediction of URA, PUVA, BND and serum 25(OH)D for PSUI was 0.859, and the sensitivity was 77.50%, specificity was 84.17%. The ICI-Q-SF scores of PSUI patients were positively correlated with URA, PUVA, BND and negatively correlated with serum 25(OH)D level (P<0.05). URA, PUVA, BND, and serum 25(OH)D were important factors influencing the occurrence of PSUI (P<0.05). In a word, the pelvic floor ultrasound parameters URA, PUVA, BND and serum 25(OH)D level are closely related to the state of illness, and have high application value in predicting PSUI.
    Evaluation of Four-dimensional Hysterosalpingo-contrast Sonography Combined with Intrauterine Pressure Measurement on the Status of Fallopian Tube
    PENG Danni, FU Yuanchun, KUANG Haiyan, LUO Yingchun
    2020, 38(6):  977-981.  DOI: 10.7517/issn.1674-0475.200515
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    98 cases of infertility patients were selected as the research object. The detection of tubal fluid through the laparoscope was the gold standard, and 4D-HyCoSy tests were performed. The contrast injection device was used for contrast injection and intrauterine pressure monitoring. The results showed that the peak pressure in the uterine cavity increased as the degree of fallopian tube obstruction increased, and the coincidence rate of 4D-HyCoSy combined with uterine cavity pressure measurement to diagnose tubal patency was higher than that of 4D-HyCoSy single diagnosis (P<0.05). It is suggested that 4D-HyCoSy combined with uterine cavity pressure measurement help to improve the diagnostic efficiency on tubal patency. This method is expected to become one of the common methods for screening tubal patency in primary hospitals, and provide evidence-based support for the personalized diagnosis and treatment of tubal infertility (TIF).
    Diagnostic Value of CT Combined with Serum Tumor Markers in Cervical Cancer Patients with Retroperitoneal Lymph Node Metastasis
    HAN Qianqian, BU Dao
    2020, 38(6):  982-987.  DOI: 10.7517/issn.1674-0475.200517
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    122 cases of cervical cancer patients were selected as the research object. According to the results of pathological examination, they were divided into metastasis group (28 patients with retroperitoneal lymph node metastasis) and non-metastasis group (94 patients without retroperitoneal lymph node metastasis). All of them were subjected to CT examination of the whole abdomen and detection of serum tumor markers including carcinoembryonic antigen (CEA), cancer antigen 125 (CA125) and squamous cell carcinoma antigen (SCC-Ag). The results showed that the shortest diameter of CT lymph nodes in the metastatic group was longer than that in the non-metastatic group, and the levels of serum CEA, CA125 and SCC-Ag were higher than those in the non-metastatic group (P<0.05). Serum CEA, CA125, SCC-Ag levels were positively correlated with the shortest diameter of the lymph nodes in the horizontal axis of CT, and the sequence of AUC value for diagnosis of retroperitoneal lymph node metastasis was:CT combined with serum tumor markers > the shortest diameter of CT lateral axis lymph node > SCC-Ag > CEA > CA125. It can provide an objective basis for clinical preoperative evaluation of the presence of retroperitoneal lymph node metastasis.
    Study on the Evaluation Effect and Predictive Effectiveness of Two-dimensional and Three-dimensional Ultrasound Parameters on Cardiac Function and Shape after Heart Transplantation
    WU Wenfang, LI Miao, DONG Jing
    2020, 38(6):  988-993.  DOI: 10.7517/issn.1674-0475.200607
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    In order to explore the application value of two-dimensional and three-dimensional echocardiography in evaluating cardiac function and morphological changes after heart transplantation,a total of 41 patients underwent heart transplantation were selected as the observation group, and 41 patients underwent healthy physical examination during the same period were selected as the control group. 7 days after surgery, two-dimensional and three-dimensional ultrasound examinations were performed. It was found that the left atrial inner diameter (LAD), left ventricular end-systolic diameter (LVESD) of the observation group were greater than those of the control group at 7 days after operation, and the left ventricular ejection fraction (LVEF) was lower than the control group (P<0.05). After 3 months of follow-up, LAD, LVESD and left ventricular mass(LVM) of those occurred rejection in the observation group were greater than those without rejection, and LVEF and left ventricular stroke volume (LVSV) were less than those without rejection (P<0.05). After 3 months of follow-up, LAD, LVESD, LVM of the deceased in the observation group were greater than those of the survivor, and LVEF and LVSV were less than those of the survivor(P<0.05). The combination of LAD, LVESD, LVEF, LVM and LVSV to predict the rejection and prognosis of patients after heart transplantation had the largest AUC. It is suggested that two-dimensional and three-dimensional ultrasound parameters have a certain evaluation value for cardiac function and morphology after heart transplantation, and they are expected to become a potential method to predict rejection and prognosis after heart transplantation, and to guide the reasonable treatment to improve the prognosis of patients.
    The Clinical Study of Diagnostic Value in Primary Testicular Lymphoma by Methods of Ultrasound, CT and MRI
    HU Xingrong, ZHU Xin, GUI Dan, ZHAO Huiyan, CHEN Huadong, HUANG Zhihua
    2020, 38(6):  994-999.  DOI: 10.7517/issn.1674-0475.200304
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    To investigate the clinical value of ultrasonography, CT and MRI in the diagnosis of primary testicular lymphoma (PTL). To analyze the clinical data, histopathology, ultrasound, CT and MRI features of 11 patients with PTL confirmed by operation and pathology retrospectively,and compared with the postoperative pathological results. There were 11 sides of testis with low and slightly low echo and 6 sides with uneven echo in 10 cases. CDFI showed that there were abundant blood flow signals in hypoechoic area of testis.6 sides of testis in 5 patients showed equal or slightly low density, unclear boundary, and medium or even enhancement. In 11 patients, 13 testicular tumors showed diffuse mass on MRI, while on T1WI, they all showed uniform and low signal. On T2WI, 6 testicular tumors showed uniform and low signal, 3 testicles showed mixed signal with low signal, 4 testicles showed slightly high signal. The postoperative pathology was diffuse large B cell lymphoma. Ultrasound, CT and MRI have their own advantages in the diagnosis of PTL, and each has a relatively specific sign. Combined with three examination methods, it is helpful for diagnosis and differential diagnosis.
    Application of Shear Wave Elastography and Superb Microvascular Imaging on Diagnosis of Benign Breast Lesions and Malignant Tumor
    CHU Xin, AN Xiaoxia, YAN Jianbo, ZHANG Hongmei
    2020, 38(6):  1000-1004.  DOI: 10.7517/issn.1674-0475.200324
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    The application of shear wave elastography (SWE) and superb microvascular imaging (SMI) on diagnosis of benign breast lesions and malignant tumor was studied. 128 breast masses patients were chosen and assigned to benign group and malignant group according to pathological examination or aspiration biopsy results. SWE and SMI were performed. Results showed that elasticity maximum of normal tissue (Emax2) between groups showed no significant difference (P>0.05); Elasticity maximum of malignant masses (Emax1) and Eratio (Emax1/Emax2) values in malignant group were significantly higher than those of benign group (P<0.05). Diagnosis sensitivity, accuracy and area under the curve based on combined examination was significantly higher than that of single examination (P<0.05). It was found that SWE combined with SMI could increase the diagnosis sensitivity and accuracy of breast tumor.
    The Value of Transabdominal Ultrasound Combined with HCG and AFP in the Diagnosis of Pernicious Placenta Previa with Placenta Accreta
    TANG Yukun, YU Ming, ZHI Ruijuan, BA Shuang, PAN Ruike, ZHANG Shuqin
    2020, 38(6):  1005-1009.  DOI: 10.7517/issn.1674-0475.200414
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    The application value of transabdominal ultrasound (TAUS) combined with human chorionic gonadotropin (HCG) and alpha fetoprotein (AFP) in the diagnosis of pernicious placenta previa (PPP) with placenta accreta (PA) is analyzed in this study. 73 patients with PPP were divided into placental implantation group (31 cases) and non placental implantation group (42 cases), while 35 cases healthy pregnant women as control group. The levels of HCG and AFP and TAUS were examined before delivery. The results showed that the levels of HCG and AFP in placental implantation group were higher than those of non placental implantation group and control group (P<0.05). The AUC, sensitivity and specificity of TAUS combined with HCG and AFP in the diagnosis of PPP with PA were 0.912, 96.8% and 85.7%, respectively, which were higher than those of single test (P<0.05). Therefore, it has a certain value of HCG and AFP in the diagnosis of PPP with PA, and combination with TAUS can improve the diagnosis efficiency.
    The Influence of MRI Combined with TRUS Examination on the Detection Rate of Prostate Cancer Puncture
    SHI Feng, SHU Song, WU Ming, YU Xintang, WANG Zengqiang
    2020, 38(6):  1010-1013.  DOI: 10.7517/issn.1674-0475.200308
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    To investigate the effect of MRI combined with TRUS on the detection rate of prostate cancer.The clinical data of 150 patients with suspected prostate cancer were analyzed retrospectively. All patients were given puncture biopsy. According to the puncture guidance, they were divided into group A, group B and group C. Group A was punctured under the guidance of TRUS, group B under the guidance of MRI, and group C under the guidance of MRI combined with TRUS. Kappa test was used to analyze the consistency between the examination methods and the surgical pathological diagnosis. The complication rate of the three groups was recorded. The results showed that the consistency of group A, group B and group C with pathological diagnosis was 0.505, 0.585 and 0.664, respectively. There was no significant difference in the incidence of bloody stool, urine retention, hematuria and low fever between the three groups (P>0.05).Compared with MRI alone or TRUS guided prostate puncture, MRI combined with TRUS guided prostate puncture had the highest consistency with surgical pathological diagnosis.
    Early Diagnostic Effects of the Different Sequence Weighted Magnetic Resonance Imaging in the Hypertensive Intracerebral Hemorrhage
    YAN Xiaolan, LIU Hongcui
    2020, 38(6):  1014-1017.  DOI: 10.7517/issn.1674-0475.200321
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    The 94 patients with hypertensive intracerebral hemorrhage were selected as subjects. All patients underwent T1WI, T2WI and SWI weighted magnetic resonance imaging. The results showed the early diagnosis rates of SWI sequences were significantly higher than those of T1WI and T2WI sequences. 125 cases of hemorrhage were finally detected. The positive rates of hemorrhagic foci in SWI sequences were significantly higher than T1WI and T2WI sequences. T1WI and T2WI sequences showed high signal shadows and clear boundaries, SWI sequence showed a clearer boundary and range of bleeding foci than T1WI and T2WI sequences. The value of SWI in the early diagnosis of hypertensive intracerebral hemorrhage is satisfying, which can accurately detect the hemorrhage foci, and has high image quality.
    Consistency Analysis of Transvaginal Three-dimensional Ultrasound and MRI in Preoperative Evaluation of Endometrial Cancer
    ZHAO Yingqin, XU Jia, HUANG Yiting, ZHAO Heng
    2020, 38(6):  1018-1022.  DOI: 10.7517/issn.1674-0475.200405
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    In order to study the consistency of transvaginal three-dimensional ultrasound (3D-TVS) and magnetic resonance imaging (MRI) in the patients with endometrial carcinoma, 356 cases of endometrial carcinoma were selected as subjects. All patients accepted 3D-TVS and MRI before surgery. The consistency of preoperative assessment in endometrial cancer of these two methods were analyzed respectively from the tumor size, muscle layer infiltration, cervical infiltration, lymph node metastasis and tumor stage and so on. The results showed that the ICC of 3D-TVS and MRI on tumor diameter was less than 0.7, which indicated good consistency. The P values of preoperative evaluation of 3D-TVS and MRI on muscular layer infiltration, cervical infiltration, lymph node metastasis and tumor stage were all less than 0.05, suggesting that all Kappa values were consistent. The Kappa value of cervical infiltration was 0.913, showing a high consistency. In conclusion, 3D-TVS and MRI showed strong consistency in preoperative evaluation of patients with endometrial cancer, and both of them could provide effective reference for surgeons.
    Application of Multislice Spiral CT in the Differential Diagnosis of Pancreatic Associated Cystic Tumors
    LIANG Shengzhong, SANG Haiyan, JIA Changling
    2020, 38(6):  1023-1026.  DOI: 10.7517/issn.1674-0475.200406
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    In order to analyze the value of multi-slice spiral CT (MSCT) in the differential diagnosis of pancreatic associated cystic tumors, 82 patients with pancreatic cystic tumors were selected as subjects. All patients were given an MSCT examination. Pathological diagnosis was taken as the gold standard to evaluate the diagnostic value of MSCT. The results showed that the coincidence rate of MSCT and pathology was 96.34%. Most serous cystadenomas were lobulated and multicystic. The maximum diameter of a single cystic cavity was less than 2 cm. Most of the mucinous cystadenomas were multilocular cystic masses. The maximum diameter of single cystic cavity in the lesions was greater than 2 cm. Mucinous cystadenocarcinoma showed a single round low-density shadow with a clear margin and no lobulation. Therefore, MSCT has high sensitivity in the diagnosis of pancreatic cystic tumors, and different lesions have their imaging features, which provides an effective reference for the differential diagnosis of pancreatic cystic tumors.
    The Screening Value of Cerebral Hemodynamics by Head Ultrasound for Hypoxic Ischemic Encephalopathy
    JI Yamei, CAI Teng
    2020, 38(6):  1027-1031.  DOI: 10.7517/issn.1674-0475.200407
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    The screening value of cerebral hemodynamics by head ultrasound for the hypoxic ischemic encephalopathy (HIE) is analyzed in this study. 1364 newborns were enrolled. The cerebral hemodynamics of middle cerebral artery (MCA) of all newborns was detected by the head ultrasound, including the end diastolic velocity (VD), peak systolic velocity (VS) and resistance index (RI). With the clinical diagnosis to be control, the screening value of VD, VS, RI of MCA for HIE was analyzed. The result showed that there were 50 newborns (3.67%) suffering from HIE. The VD in the HIE newborns was significantly lower than that in the non-HIE newborns, while the VS and RI in the HIE newborns were significantly higher than those in the non-HIE newborns (P<0.05). The sensitivity, specificity and accuracy of screening with the combination of the VD, VS, RI was significantly higher than single of them (P<0.05). From above results, it can be concluded that the cerebral hemodynamics has the good screening value for the HIE, and the combined detection is superior to a separate one.
    Risk Factors Related to Central Lymph Node Metastasis in Papillary Thyroid Microcarcinoma
    TAN Xueli, LIU Shichu, ZHONG Xiaoling, LIU Rongbin
    2020, 38(6):  1032-1037.  DOI: 10.7517/issn.1674-0475.200409
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    The incidence of papillary thyroid microcarcinoma (PTMC) is increasing year by year. Central lymph node metastasis (CLNM) is one of the important prognostic factors for the patients of PTMC. A retrospective study was performed on 198 patients with cN0 PTMC (tumor diameter ≤ 10 mm). Basic data (e.g., gender, age, tumor location, tumor diameter) of eligible patients were extracted, as well as the pathology, ultrasound, fine-needle aspiration cytology (FNAC) results and BRAFV600E mutation analysis. The results of univariate analysis indicated that age <45 years, male, punctate echogenic foci on sonography, tumor size ≥ 5 mm, and ACR TI-RADS scores ≥ 8 were related to predict CLNM in PTMC patients. The results of multivariate analysis indicated that tumor size ≥ 5 mm, punctate echogenic foci on sonography, and ACR TI-RADS scores ≥ 8 were independent risk factors for CLNM. Moreover, larger tumor volume and higher TI-RADS scores were associated with greater risk of CLNM in cN0 PTMC patients, whom clinicians should take a more radical treatment strategy for.
    Clinical Value of MRI in the Diagnosis of Small Hepatocellular Carcinoma with Disodium Gadolinium Sephate in the Context of Liver Cirrhosis
    FAN Xiaoli, LING Qian, FANG Zheng, ZHU Xiaoling
    2020, 38(6):  1038-1042.  DOI: 10.7517/issn.1674-0475.200410
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    To explore the diagnostic value of MRI combined with Gd-EOB-DTPA for small liver cancer. 80 patients underwent upper abdominal MRI and Gd-EOB-DTPA enhanced MRI. The probability of detecting small liver cancer with two methods, ROC curve, and sensitivity, negative, positive predictive value were compared. The results showed that a total of 95 small nodules were detected in 80 patients, 76 were diagnosed with HCC, and 19 were benign nodules. The probability and AUC value of MRI combined with Gd-EOB-DTPA for the diagnosis of small hepatocellular carcinoma were significantly higher than those of MRI alone (P<0.05). The sensitivity, negative and positive predictive values of MRI combined with Gd-EOB-DTPA for the diagnosis of small liver cancer are higher than those of MRI alone, but there is no significant difference (P>0.05).Gd-EOB-DTPA enhanced MRI can improve the diagnosis rate and sensitivity of small liver cancer in the background of cirrhosis, and it is worthy of clinical promotion.
    Differential Diagnosis of Fibroadenosis of Breast in Women by Multimodal Magnetic Resonance
    TONG Ying, MI Nan, ZHANG Rong, XING Qianchao, CAO Zhendong
    2020, 38(6):  1043-1046.  DOI: 10.7517/issn.1674-0475.200412
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    In order to explore the clinical value of multimodal MRI in the diagnosis of women's breast simple fibroadenosis and mixed fibroadenosis,146 cases of female patients with fibroadenosis of breast were selected as the research objects, and multimodal magnetic resonance examination was performed. Multimodal MRI features were compared and found that the lump size ≥ 10 mm of the simple fibroadenosis group was 82.22%, and the lump size ≥ 10 mm of the mixed fibroadenosis group was 43.33%. Comparison of diagnostic efficacy parameters found that the ADC value and peak signal strength of the simple fibroadenosis group were lower than those of mixed fibroadenosis group(P<0.05). The ADC value and peak signal strength of multimodal MRI were highly effective in predicting simple fibroadenosis and mixed fibroadenosis.
    The Screening Value of Prenatal Ultrasound for Fetal Central Nervous Malformation in Early and Mid Pregnancy
    CAI Teng, JI Yamei
    2020, 38(6):  1047-1051.  DOI: 10.7517/issn.1674-0475.200501
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    The value of prenatal ultrasound in screening for fetal central nervous system malformations (CNSM) in early pregnancy and mid pregnancy was analyzed. 2298 pregnant women were selected as the subjects of this study, who were given prenatal ultrasound examination in early pregnancy (11-13+6 weeks) and mid pregnancy (14-27+6 weeks). The postpartum ultrasound or pathological examination showed that there were 200 cases (8.70%) of fetal CNSM. The coincidence rate of fetal CNSM in early pregnancy combined with mid pregnancy ultrasound was significantly higher than that in early pregnancy (P<0.05). The sensitivity, specificity and accuracy of early pregnancy combined with mid pregnancy ultrasound was significantly higher than those of early pregnancy (P<0.05). This study confirms that the prenatal ultrasound screening of fetal CNSM can be brought forward to early pregnancy, which is beneficial to early screening of fetal CNSM. But in order to have better screening effect, it still needs to be supplemented by ultrasound in mid pregnancy.
    Clinical Diagnostic Value of Multi-slice Spiral CT Post-processing Technique Applied to Sinus-nasal Complex Mutation and Sinusitis
    XU Lina, YANG Lei, SHI Yarong, YUN Jia, JIN Qiuyan, PAN Qingyun, MIN Hao
    2020, 38(6):  1052-1055.  DOI: 10.7517/issn.1674-0475.200506
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    To explore the value of multi-slice spiral CT post-processing technology in the diagnosis of sinus-nasal complex and sinusitis.112 patients with chronic sinusitis were selected as the subjects. The plane reconstruction of multi-slice spiral CT was used to observe the anatomical variation of the sinus-nasal complex and the inflammation of the sinuses. The results showed that the vesicular turbinate accounted for the largest proportion of the anatomical variation of the sinus ostium-nasal canal complex in 112 patients, reaching 30.36%, followed by nasal septum deviation (23.21%) and uncinate hypertrophy (13.39%). Among the 112 patients with nasal-sinus inflammation distribution, the anterior group had the largest proportion of ethmoid sinus, reaching 88.39%, followed by maxillary sinus ostia (69.64%) and maxillary sinus (66.07%). In 23 cases of functional endoscopic sinus surgery, the endoscopic findings of the lesions were consistent with the CT display. It is concluded that the use of multi-slice spiral CT post-processing technology has an important role in the anatomical structure and variation of the sinus-nasal tract complex in patients with sinusitis.
    Application Value of Color Doppler Ultrasound in Microsurgery and Perioperative Monitoring of Cerebral Hemodynamics in HICH
    FAN Shaoping, AN Mo, YANG Bo, LYU Chunchao, LIANG Bixian, LI Jiao
    2020, 38(6):  1056-1060.  DOI: 10.7517/issn.1674-0475.200510
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    The application value of color Doppler ultrasound in microsurgery and perioperative monitoring of cerebral hemodynamics in hypertensive intracerebral hemorrhage (HICH) is analyzed in this study. 87 patients with HICH were divided into ultrasound-guided group and conventional operation group. The hemodynamic parameters of middle cerebral artery were monitored by transcranial color Doppler ultrasound. The clearance rate of hematoma, incidence of cerebral infarction, short-term and long-term effects were compared. The results showed that the clearance rate of hematoma of ultrasound-guided group was higher than that of conventional operation group on the 2 days postoperative (P<0.05), the incidence of cerebral infarction was lower than that of conventional operation group on the 7 days postoperative (P<0.05), and the short-term and long-term effects were better than those of conventional operation group (P<0.05). Compared with the conventional operation group, the Vs, Vd, Vm of ultrasound-guided group were increased, PI was decreased on the 7 days postoperative (P<0.05). Therefore, color Doppler ultrasound is an effective method to monitor the changes of cerebral hemodynamics in HICH. Real-time ultrasound guidance can accurate the location of intracranial hematoma, improve the clearance rate of hematoma, and improve the prognosis.
    Evaluation of Systolic and Diastolic Right Ventricular Function in Patients with Mild Mitral Stenosis by Doppler Echocardiography
    WEN Jia, ZHANG Min, PAN Li, GUO Liping, QIN Lang
    2020, 38(6):  1061-1064.  DOI: 10.7517/issn.1674-0475.200512
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    50 patients with mild mitral stenosis were selected as the observation group, and another 50 patients with aortic valve insufficiency were selected as the reference group. Systolic and diastolic right ventricular function of the two groups were evaluated by Doppler echocardiography. The results showed that there were significant differences in mitral valve orifice area, right ventricular ejection fraction, right ventricular diameter, interventricular septal end diastolic thickness, right ventricular anteroposterior diameter, right ventricular regional end diastolic volume and right ventricular local end systolic volume of the inflow tract, outflow tract, right ventricle, and apical muscle trabeculae between the two groups (P<0.05). Using Doppler echocardiography to evaluate mild mitral stenosis has important clinical reference value for early risk assessment of patients.
    Quantitative Evaluating of the Left Ventricular Muscle Function before and after PCI in Patients with Coronary Heart Disease by 2D-STI
    DAI Yanyan, YANG Xiuling, LIANG Suozhu, WANG Jianshuang
    2020, 38(6):  1065-1069.  DOI: 10.7517/issn.1674-0475.200518
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    To investigate the application value of 2D-STI in evaluating the left ventricular muscle function before and after PCI in patients with coronary heart disease, fifty patients with coronary heart disease (PCI group) who underwent PCI successfully were selected as PCI group, fifty healthy patients were taken as control group. The ultrasound indicators, 2D-STI parameters were compared in the two groups. The results showed, compared with the control group, the preoperative A peak elevated (P<0.05), E/A value and LVEF in the PCI group reduced (P<0.05).In the PCI group,LVEF postoperative and E/A at 60 d,180 d after surgery was higher than that before surgery (P<0.05), and LVEF at 180 d after surgery was higher than that at 30 d after surgery (P<0.05). The levels of GLS, GRS and GCS before surgery in the PCI group were lower than those in the control group (P<0.05), and the levels of GLS, GRS and GCS after surgery were higher than those before surgery (P<0.05), GRS and GCS were further increased at 180 d after surgery compared with 30 d after surgery (P<0.05).The levels of GLS, GRS and GCS in the PCI group were lower than those in the control group at each time point after surgery (P<0.05). GLS and GCS were negatively correlated with LVEF (P<0.05), while GRS was positively correlated with LVEF (P<0.05). The results indicated that 2D-STI can be used to evaluate left ventricular myocardial function after interventional treatment of coronary heart disease.
    The Therapeutic Effect of HLL Under Continuous Irrigation of Epidural Catheter in Ureteral Calculi with High CT Value
    LIU Qiang, SHAO Jinghui, ZANG Hongxue, LI Shuaibiao
    2020, 38(6):  1070-1075.  DOI: 10.7517/issn.1674-0475.200519
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    The aim of this research is to explore the therapeutic effect of holmium laser lithotripsy (HLL) under continuous irrigation by epidural catheter in the treatment of ureteral calculi of high CT value. A total of 106 patients with ureteral calculi of high CT values were divided into two groups by random number table. The control group adopted HLL under ureteroscopy, and the observation group adopted HLL under continuous irrigation by epidural catheter. The operation time of the observation group was shorter than that of the control group, while the success rate of lithotripsy was higher than that of the control group, and the rate of stone uplift and in vitro lithotripsy was lower than that of the control group (P<0.05). One day after surgery, the adrenaline (AE), cortisol (Cor), and malondialdehyde (MDA) of the observation group were lower than those of the control group, while the superoxide dismutase (SOD) was higher than that of the control group. Three days after surgery, the interleukin-1 (IL-1), tumor necrosis factor-α (TNF-α) and IL-6 in the observation group were lower than those in the control group (P<0.05). The incidence of complications in the observation group (3.77%) was significantly lower than that in the control group (15.09%). It is suggested that HLL under continuous irrigation by epidural catheter is more effective in treating ureteral calculi of high CT value.
    Association Analysis of Ultrasound Contrast Parameters with Proliferation Gene Expression and Lymph Node Metastasis of Differentiated Thyroid Cancer
    WANG Chunmei, WANG Lili
    2020, 38(6):  1076-1081.  DOI: 10.7517/issn.1674-0475.200521
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    In this paper, 82 patients with differentiated thyroid cancer were selected as the malignant group, and 82 patients with benign thyroid nodules were selected as the benign group. All were performed ultrasound contrast, as well as the detection of proliferation gene expression in tumor tissue and lymph node metastasis of differentiated thyroid cancer. It was found that the levels of PI, MTT, and TTP in the malignant group were lower than those in the benign group, while the expression levels of Twist1 and TPX2 mRNA in tumor specimens in the malignant group were higher than those in the benign group. In addition, the expression levels of PP4R1 and PDCD4 mRNA were lower than those in the benign group. The ultrasound contrast parameters were negatively correlated with the expression of Twist1 and TPX2 mRNA in tumor tissue samples, and positively correlated with the expression of PP4R1 and PDCD4 mRNA (P<0.05). The AUC value of combination of PI, MTT and TTP to predict the lymph node metastasis of differentiated thyroid cancer was higher than that predicted by a single index. It is suggested that the abnormalities of ultrasound contrast parameters are directly related to the changed expression of proliferating genes and lymph node metastasis. By ultrasonography, we can quantify the proliferation and invasion activity of thyroid cancer tumor cells.
    Predictive Value of Ultrasound Parameters Combined with Progesterone and β-hCG on Spontaneous Abortion in Early Pregnancy
    FAN Hongyan, LIANG Tiantian
    2020, 38(6):  1082-1087.  DOI: 10.7517/issn.1674-0475.200603
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    224 pregnant women were selected as the research object, followed up to 28 gestational weeks, and divided into abortion group and non-abortion group. The ultrasound parameters including fetal heart rate (FHR), crown-rump length (CRL), mean gestational sac diameter (MSD), mean sac diameter-crown-rump length (MSD-CRL) in early pregnancy of two groups were compared, as well as serum progesterone and β-hCG levels. Besides the influencing factors of spontaneous abortion, the correlation between ultrasound parameters and serum progesterone and β-hCG were analyzed too. In addition, the predictive value of the above indexes for spontaneous abortion was evaluated. The results showed that the FHR of the abortion group was lower than that of the non-abortion group, the MSD and MSD-CRL were shorter than that of the non-abortion group, and the serum progesterone and β-hCG levels were lower than that of the non-abortion group (P<0.05). The history of miscarriage, irregular intake of folic acid before and after pregnancy, husband smoking during pregnancy, FHR, MSD, MSD-CRL,progesterone, β-hCG in early pregnancy were important influencing factors for spontaneous abortion (P<0.05). FHR, MSD, MSD-CRL in early pregnancy were positively correlated with serum progesterone and β-hCG (P<0.05). The efficacy of FHR, MSD, MSD-CRL combined with serum progesterone and β-hCG on spontaneous abortion in early pregnancy was better than the above indicators alone. In conclusion, ultrasound parameters such as FHR, MSD, MSD-CRL and progesterone, β-hCG in early pregnancy are important influencing factors of spontaneous abortion, and the combined detection has good predictive value.
    Application Value of Magnetic Resonance IVIM Imaging in Predicting TN Stage, Differentiation and Vascular Invasion of Rectal Cancer
    DUAN Shufeng, FENG Feng
    2020, 38(6):  1088-1093.  DOI: 10.7517/issn.1674-0475.200604
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    To explore the value of magnetic resonance IVIM imaging in the prediction of TN staging, differentiation and vascular invasion of rectal cancer. Routine MRI and IVIM scanning were performed in 43 patients with rectal cancer. The IVIM parameters of the lesions were obtained and analyzed by post-processing software, then surgeries were performed within one week and the tumors were sent for pathological examination. As the T stage increased, the D value decreased and the D* value increased (P<0.05).The lower the pathological differentiation degree of rectal adenocarcinoma, the lower the D value and the higher the D* value (P<0.05).The D value was statistically significant between the two groups of rectal cancer with or without lymph node metastasis(P<0.05).The IVIM parameters were not statistically significant between the two groups with or without vascular invasion of rectal cancer (P>0.05). Therefore,D and D* value can assist in the T staging of rectal cancer and predict the degree of pathological differentiation. D value is also useful in the diagnosis of lymph node metastasis.