Abstract: The study discussed the relationship between liver/spleen CT value, hepatic parenchymal perfusion parameters and hepatic fibrosis degree and predicted the reactive value of anti-fibrosis therapy. 110 patients with liver fibrosis of chronic hepatitis B treated (observation group), 100 healthy volunteers were selected as the control group. The CT value of liver/spleen, portal vein perfusion (PVP), total hepatic perfusion (TLP), hepatic blood flow (HBF) and blood volume (BV) in the observation group were significantly lower than those in the control group (P<0.05). The hepatic arterial perfusion (HAP) and the hepatic perfusion index (HPI) were significantly higher than that of the control group (P<0.05). CT value of liver/spleen, PVP, TLP, HBF and BV were negatively correlated with the degree of liver fibrosis. HAP and HPI were positively correlated with the degree of liver fibrosis. The area under the ROC curve of CT value of liver/spleen, HAP, PVP and TLP to judge the therapeutic effect were 0.661, 0.745, 0. 885 and 0.820, P<0.05. The CT value of liver/spleen and hepatic parenchymal perfusion parameters are correlated with the degree of liver fibrosis, which is valuable in predicting the response of antifibrotic therapy.

Key words: CT value of liver/spleen, hepatic parenchymal perfusion parameters, degree of liver fibrosis, antifibrotic therapy