Abstract: This study was to investigate the value of multimodal magnetic resonance imaging (MRI) parameters in the diagnosis of neonatal hypoxic-ischemic encephalopathy. A total of 54 neonates with mild hypoxic-ischemic encephalopathy and 34 neonates with moderate hypoxic-ischemic encephalopathy were selected, and received conventional MRI scan, diffusion tensor imaging and light proton magnetic resonance spectrum scan. The fractional anisotropy (FA) values of posterior limb and thalamus, N-acetylaspartate (NAA)/creatine (Cr) and NAA/choline complex (Cho) in moderate group were significantly lower than those in mild group (P<0.05). The area under ROC curve of basal ganglia score, watershed score, FA value of posterior limb of internal capsule, FA value of thalamus, NAA/Cr and NAA/Cho in the differentiation of mild to moderate neonatal hypoxic-ischemic encephalopathy were all more than 0.700 (P<0.05), while the sensitivity and specificity of combined detection reached 96.00% and 98.00%. MRI multimodal parameters have a good value in the diagnosis of neonatal hypoxic-is chemic encephalopathy, has a certain value in differentiating the degree of the disease.

Key words: multimodal parameters, magnetic resonance imaging, newborn, hypoxic ischemic encephalopathy