烟草花叶病毒的特定位点改性及应用

doi:10.7517/j.issn.1674-0475.2017.04.011

摘要/Abstract

摘要：

病毒是自然界中已知结构最简单却侵染能力极强的生物，作为一种典型的一维棒状植物病毒，烟草花叶病毒（TMV）具有单分散的形貌与尺寸（18 nm × 300 nm）、明确的空间结构、丰富的表面化学基团，且对哺乳动物不具有致病性，已广泛应用于电子器件、传感、成像、生物医用材料的研究。本文简述了对TMV进行基因工程或化学改性的多种方法及应用进展，并主要介绍了烟草花叶病毒在生物医用材料领域的潜在应用。

关键词: 烟草花叶病毒, 基因工程, 化学改性, 生物医用材料

Abstract:

Viruses behave the simplest structure yet a high transfection efficiency in nature. As a classic 1-dimensional rod-like plant virus, tobacco mosaic virus (TMV) has the monodispersed morphology and size (18 nm × 300 nm), well-defined spatial structure, abundant chemical groups on surfaces, and non-infection to mammals. Thus, TMV has received great research interest in electronic devices, sensing, imaging and biomedicine. In this review, we will introduce the gene and chemical modifications for TMV and its potential applications, especially in the field of biomedical materials.

Key words: tobacco mosaic virus, gene engineering, chemical modification, biomedical materials

田野, 朱萌, 牛忠伟. 烟草花叶病毒的特定位点改性及应用[J]. 影像科学与光化学, 2017, 35(4): 494-505.

TIAN Ye, ZHU Meng, NIU Zhongwei. Site-specific Modification of Tobacco Mosaic Virus and Its Applications[J]. Imaging Science and Photochemistry, 2017, 35(4): 494-505.

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