19F磁共振成像造影剂研究进展

doi:10.7517/issn.1674-0475.200201

摘要/Abstract

摘要： 19F磁共振成像（19F magnetic relaxation imaging，19F MRI）技术因其无内源性背景噪声而被广泛应用于生物医学研究领域。磁共振成像技术被提出后，19F MRI造影剂的研究主要集中于全氟化碳类有机物，这类有机物具有高的19F载量、合适的弛豫时间、高的影像信噪比，同时可以通过修饰功能性的基团实现多模式造影。近年来，19F MRI造影剂由全氟化碳等有机物逐渐向无机物延伸，出现了无机氟化物纳米粒子造影剂。本文主要介绍了19F MRI造影剂的种类、研究现状和应用前景。

关键词: 19F磁共振成像, MRI造影剂, 全氟化碳, 氟化钙

Abstract: Because of no background noise in vivo, 19F magnetic relaxation imaging (19F MRI) has been widely used in biomedical research. Perfluorocarbons molecules are the main kinds of 19F MRI imaging tracers. The organic fluoride can achieve high 19F density, suitable relaxation time, high signal to noise ratio, as well as multimodal imaging by modification with functional groups. In recent years, 19F MRI imaging tracers have been gradually developed from organic compounds to inorganic compounds. In this review, we summarized the types, research status and application prospects of 19F MRI imaging tracers.

Key words: 19F MRI, MRI imaging tracer, perfluorocarbons, calcium fluoride

孟凡强, 刘燕, 吴勇杰, 陶可, 孙康. 19F磁共振成像造影剂研究进展[J]. 影像科学与光化学, 2020, 38(5): 753-762.

MENG Fanqiang, LIU Yan, WU Yongjie, TAO Ke, SUN Kang. Research Progress on 19F Magnetic Resonance Imaging Tracer[J]. Imaging Science and Photochemistry, 2020, 38(5): 753-762.

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