磁共振延迟强化技术与HCM患者血浆NT-proBNP、Hcy变化的关系

doi:10.7517/issn.1674-0475.201118

影像科学与光化学 ›› 2021, Vol. 39 ›› Issue (3): 391-395.DOI: 10.7517/issn.1674-0475.201118

磁共振延迟强化技术与HCM患者血浆NT-proBNP、Hcy变化的关系

刘铁芳, 胡坚兴, 张晓晶

解放军总医院第一医学中心, 北京 100853

收稿日期:2020-11-17 出版日期:2021-05-15 发布日期:2021-05-17
通讯作者: 张晓晶

The Relationship between the Parameters of MRI-LGE and the Changes of Plasma NT-proBNP and Hcy in Patients with Hypertrophic Cardiomyopathy

LIU Tiefang, HU Jianxing, ZHANG Xiaojing

The First Medical Center of PLA General Hospital, Beijing 100853, P. R. China

Received:2020-11-17 Online:2021-05-15 Published:2021-05-17

摘要/Abstract

摘要： 本文探讨了磁共振延迟强化（MRI-LGE）与肥厚型心肌病（HCM）患者血浆氨基末端脑钠肽前体（NT-proBNP）、同型半胱氨酸（Hcy）水平变化的关系。选取HCM患者76例作为研究对象，所有患者均接受心脏MRI检查，根据LGE结果分为LGE阳性组和LGE阴性组，对比两组的总LGE率、LGE体积、LGE质量、NT-proBNP、Hcy水平，并分析NT-proBNP、Hcy水平与LGE参数的相关性。结果显示，LGE阳性组患者的总LGE率、LGE体积、LGE质量均显著高于LGE阴性患者（P<0.05）；LGE阳性组患者的NT-proBNP、Hcy测定值高于LGE阴性患者（P<0.05）；LGE阳性HCM患者NT-proBNP、Hcy测定值与总LGE率、LGE体积、LGE质量均呈显著的正相关关系（P<0.05）。HCM伴有心肌纤维化患者的NT-proBNP、Hcy明显升高，且与纤维化程度有关。

关键词: 磁共振延迟强化, 延迟钆增强, 肥厚型心肌病, 氨基末端脑钠肽前体, 同型半胱氨酸

Abstract: In this study, the relationship between the parameters of late gadolinium enhancement(LGE) and the changes of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and homocysteine (Hcy) in patients with hypertrophic cardiomyopathy (HCM) was investigated. Seventy-six HCM patients were selected as research objects. All patients underwent cardiac MRI examination, they were divided into LGE-positive group and LGE-negative group according to the LGE results. The total LGE rate, LGE volume, LGE quality, NT-proBNP, Hcy levels of the two groups were compared, and the correlation between NT-proBNP, Hcy levels and LGE parameters was analyzed. The results showed that the total LGE rate, LGE volume, and LGE quality of the LGE-positive group were significantly higher than those of the LGE-negative group (P<0.05).The measured values of NT-proBNP and Hcy of LGE-positive patients were higher than those of LGE-negative patients (P<0.05).The measured values of NT-proBNP and Hcy in LGE-positive HCM patients were significantly positively correlated with the total LGE rate, LGE volume, and LGE quality (P<0.05). NT-proBNP and Hcy in HCM patients with myocardial fibrosis are significantly increased, and are related to the degree of fibrosis.391

Key words: delayed enhancement of magnetic resonance, late gadolinium enhancement, hypertrophic cardiomyopathy, N-terminal pro-brain natriuretic peptide, homocysteine

刘铁芳, 胡坚兴, 张晓晶. 磁共振延迟强化技术与HCM患者血浆NT-proBNP、Hcy变化的关系[J]. 影像科学与光化学, 2021, 39(3): 391-395.

LIU Tiefang, HU Jianxing, ZHANG Xiaojing. The Relationship between the Parameters of MRI-LGE and the Changes of Plasma NT-proBNP and Hcy in Patients with Hypertrophic Cardiomyopathy[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(3): 391-395.

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磁共振延迟强化技术与HCM患者血浆NT-proBNP、Hcy变化的关系

The Relationship between the Parameters of MRI-LGE and the Changes of Plasma NT-proBNP and Hcy in Patients with Hypertrophic Cardiomyopathy

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