Abstract: This study explored the application value of knee arthroplasty in the treatment of unicompartmental knee osteoarthritis. 103 patients with knee single compartment osteoarthritis were divided into control group (n=53) and observation group (n=50) according the operation mode, the control group was treated with single condylar replacement, and the observation group was treated with knee joint replacement, the operation time and intraoperative bleeding volume of the two groups and so on were observed. The operation time and hospitalization time in the observation group were significantly longer than that in the control group, and the intraoperative bleeding amount was significantly more than that in the control group (P<0.05). There were no significant differences between the observation group and the control group in terms of the change value of femoral anterior condyle deviation, femoral prosthesis flexion angle, tibial retroinclination angle and tibial angle (P>0.05). The serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP) in the observation group at 24 hours after operation were significantly higher than those in the control group (P<0.05). There was no significant difference in knee mobility (ROM) and New York Special Surgery Hospital knee joint (HSS) between the observation group and control group (P>0.05). There was no significant difference in the incidence of complications between the observation group and the control group (P>0.05). Knee arthroplasty has a good effect on the treatment of knee unicompartmental osteoarthritis, but it has many disadvantages, such as large trauma, large amount of bleeding and so on.

Key words: knee arthroplasty, knee unicompartmental osteoarthritis, clinical effect