Multimodal MRI Parameters Combined with Thyroid Hormones to Assess Cognitive Impairment in Cerebral Small Vessel Disease

doi:10.7517/issn.1674-0475.220719

Abstract

Abstract: This paper investigated the value and clinical significance of multimodal magnetic resonance imaging (MRI) technique combined with thyroid hormone to assess cognitive impairment in cerebral small vessel disease (CSVD). According to the presence or absence of cognitive impairment, the 112 patients with CSVD were divided into damaged group (n=49) and non-damaged group (n=63). The multimodal MRI parameters [white matter lesions (WMLs) score, volume of WMLs, number of cerebral microhemorrhages (CMBs), fraction anisotropy (FA) values, apparent diffusion coefficient (ADC) values], thyroid hormones [parathyroid hormone (PTH), triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH)] were compared between the two groups. The results showed that WMLs scores, WMLs volume, and CMBs number in the damaged group were higher than in the non-damaged group, and FA values in the basal ganglia area, parietal lobe, and frontotemporal lobe were lower than in the non-damaged group (P<0.05). PTH and TSH in the damaged group were higher than in the non-damaged group, and T3 and T4 were lower than in the non-damaged group (P<0.05). AUC of WMLs score, volume of WMLs, number of CMBs, FA value of basal ganglia area, FA value of parietal lobe, FA value of frontotemporal lobe combined with PTH, T3, T4 and TSH to assess cognitive impairment in CSVD was greater than any single index; WMLs score, volume of WMLs, number of CMBs and PTH and TSH were negatively correlated with MMSE score (P<0.001). Basal ganglia area, parietal and frontotemporal FA values and T3 and T4 were positively correlated with MMSE scores (P<0.001). Multimodal MRI parameters and thyroid hormones are associated with CSVD cognitive impairment and its severity, and the combined test can be one of the effective protocols to assess the cognitive impairment status of patients.

Key words: multimodal MRI technique, thyroid hormone, cerebral small vessel disease, cognitive impairment

WANG Xinli, ZHEN Na, YANG Hailong, ZHU Jianguo. Multimodal MRI Parameters Combined with Thyroid Hormones to Assess Cognitive Impairment in Cerebral Small Vessel Disease[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(6): 1328-1333.

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