The Role of DCE-MRI in the Evaluation of Blood-brain-barrier Alteration after Balanced Acupuncture in Migraine without Aura and Its Relationship with Analgesic Effect

doi:10.7517/issn.1674-0475.221012

Abstract

Abstract: This paper investigated the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in the assessment of blood-brain-barrier alterations after balanced acupuncture in migraine without aura and its relationship with analgesic effect. 157 patients with migraine without aura were divided into a total effective group (n=115) and ineffective group (n=42) according to the effect of balance acupuncture. Compared the DCE-MRI blood-brain barrier parameters[bilateral thalamus, basal ganglia, amygdala, white matter blood-brain barrier penetration (Ktrans), plasma fraction (Vp)] before and after 4 weeks of treatment between the two groups. The results showed that the headache degree score was lower in the total effective group than in the ineffective group, and the amygdala Vp was higher in the pre-treatment and after 4 weeks of treatment than in the ineffective group (P<0.05). The amygdala Vp was positively correlated with the treatment efficacy (P<0.001). The headache degree score and pre-treatment amygdala Vp were both independent factors influencing the analgesic effect (P<0.05), and the two combined prediction of analgesia ineffectiveness had the largest AUC. Thus Vp values of DCE-MRI can be used to reflect the efficacy of balanced acupuncture in migraine without aura, and also can be used to assess blood-brain barrier alterations, and has high diagnostic efficacy for analgesic effects.

Key words: migraine without aura, DCE-MRI, blood-brain-barrier, balanced acupuncture

ZHANG Qianqian, LI Yan, REN Hong, XIAO Aiwei, LIU Shanshan, YU Guiyong. The Role of DCE-MRI in the Evaluation of Blood-brain-barrier Alteration after Balanced Acupuncture in Migraine without Aura and Its Relationship with Analgesic Effect[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 11-16.

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