Study of Three-dimensional Speckle Tracking Imaging and DDIAS in the Diagnosis of Moderate and Severe Coronary Artery Stenosis

doi:10.7517/issn.1674-0475.221017

Abstract

Abstract: This study investigated the value of three-dimensional speckle tracking imaging (3D-STI) and DNA damage-induced apoptosis suppressor (DDIAS) in the diagnosis of moderate and severe coronary artery stenosis. 112 patients with suspected coronary heart disease were examined by 3D-STI, and coronary artery stenosis was confirmed by coronary angiography (CAG) within 24 hours. Based on CAG results, the patients were divided into slight, mild, moderate, and severe groups by percentage of stenosis. At the same time, 30 healthy subjects were selected as the control group. Serum DDIAS in patients with coronary heart disease and healthy subjects were detected by enzyme-linked immunosorbent assay (ELISA). The results showed that with the increase of stenosis degree, 3D-GAS, 3D-GLS, 3D-GCS and 3D-GRS all increased gradually (P<0.05). The level of serum DDIAS in patients with coronary heart disease was higher than that in healthy subjects, and the level of serum DDIAS gradually increased with the increase of stenosis degree (P<0.05). The area under the ROC curve (AUC) (0.846) and sensitivity (98.28%) of 3D-GAS for diagnosing moderate and severe coronary artery stenosis were higher, but the specificity was lower (57.41%). The AUC, sensitivity and specificity of serum DDIAS in the diagnosis of moderate and severe coronary artery stenosis were 0.910, 84.48% and 90.74%, respectively. The AUC, sensitivity and specificity of 3D-STI parameters combined with serum DDIAS in the diagnosis of moderate and severe coronary artery stenosis were 0.979, 96.55% and 96.30%, respectively. The AUC and specificity of 3D-STI parameters combined with serum DDIAS in the diagnosis of moderate and severe coronary artery stenosis were higher than those of single diagnosis, and the sensitivity was second only to that of 3D-GAS alone. It is helpful for the accurate diagnosis of coronary artery stenosis.

Key words: three-dimensional speckle tracking imaging, coronary stenosis, DNA damage-induced apoptosis inhibitor, three-dimensional global area strain

LING Jingxia, WANG Lei, DU Xin. Study of Three-dimensional Speckle Tracking Imaging and DDIAS in the Diagnosis of Moderate and Severe Coronary Artery Stenosis[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 102-108.

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