Application of SWE Combined with Chloride Channel Protein-3 in the Diagnosis of Cervical Cancer

doi:10.7517/issn.1674-0475.221035

Abstract

Abstract: This paper explored the value of real-time shear-wave elastography (SWE) combined with chloride channel protein-3 (ClC-3) in the diagnosis of cervical cancer. 105 patients with suspected cervical lesions were selected as the research objects, including 50 cases with benign lesions (benign lesion group) and 55 cases with cervical cancer (cervical cancer group). At the same time, 50 healthy people in the same period were selected as the control group. The maximum and average elastic modulus of all subjects were examined by SWE. Serum ClC-3 mRNA level was determined by real-time polymerase chain reaction(PCR). Using clinicopathological diagnosis as the gold standard, ROC curve was used to evaluate the diagnostic value of maximum elastic modulus, average elastic modulus and serum ClC-3 mRNA in cervical cancer. Compared with the control group and the benign lesion group, the maximum elastic modulus, the average elastic modulus, and the serum ClC-3 mRNA level were increased in the cervical cancer group (P<0.05). The maximum value of elastic modulus and the average value of elastic modulus were positively correlated with ClC-3 mRNA (r=0.447, P<0.001). Compared with single examination, the AUC and sensitivity of combined 142detection of the maximum elastic modulus, average elastic modulus and ClC-3 mRNA were increased (P<0.05). SWE imaging parameters and serum ClC-3 mRNA changes have a certain correlation with the occurrence of cervical cancer. SWE combined with serum CLC-3 mRNA examination has high diagnostic value for cervical cancer.

Key words: real time shear wave elastic imaging, chloride channel protein-3, cervical carcinoma

TAO Yuhua, MIAO Xian, JI Hongjuan, GU Xiaoxia. Application of SWE Combined with Chloride Channel Protein-3 in the Diagnosis of Cervical Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(1): 142-146.

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