Abstract: In order to investigate the relationship between serum galectin-3 (Gal-3) and interleukin-17 (IL-17) levels of neonatal infectious pneumonia (NIP) and pulmonary ultrasound scores, as well as the predictive value of secondary respiratory distress syndrome (RDS), 98 children with NIP were selected as the study group, and RDS children were divided according to whether they had secondary RDS. In children without RDS, 98 healthy newborns were selected as the control group. Serum Gal-3 and IL-17 levels were detected in all patients, and lung ultrasound was performed in the study group. The results showed that the levels of serum Gal-3 and IL-17 in the study group were higher than those in the control group, and the levels of serum Gal-3 and IL-17 were negatively correlated with pulmonary ultrasound scores. Gal-3 and IL-17 were independent risk factors for secondary RDS in NIP, and gestational age was independent protective factor for secondary RDS in NIP. The AUC value of the combined prediction of serum Gal-3 and IL-17 for secondary RDS in NIP was greater than that predicted by a single index, and the patients benefited well. In conclusion, serum Gal-3 and IL-17 levels are closely related to pulmonary ultrasound scores in children with NIP. Clinical detection of serum Gal-3 and IL-17 levels can assess the risk of secondary RDS in children with NIP.

Key words: neonatal infectious pneumonia, galectin-3, interleukin-17, pulmonary ultrasound score