Study of AFM Imaging and Characterization of Tumor Cells

doi:10.7517/j.issn.1674-0475.2016.03.233

Abstract

Abstract:

This article describes the history of the development of an atomic force microscope and simply introduces the working principle, working mode of atomic force microscopy (AFM), imaging methods of living cells under physiological state, etc. A special presentation biotypes atomic force microscopy, high-speed atomic force microscope in biology research and application is given in the paper. AFM with improved scanning speed, scanning range and the scanning precision will provide a steady stream of power to cytology cancer research. This paper expounds the research progress in the field of atomic force microscopy in tumors, including atomic force microscopy in tumor cells, topography characteristics, stiffness, viscoelasticity. And we also prospected the application of the atomic force microscope in tumor diagnosis and anti-tumor drugs research.

Key words: AFM, tumor, morphology characteristics, stiffness, viscoelasticity

GAO Jingwei, HAN Dong. Study of AFM Imaging and Characterization of Tumor Cells[J]. Imaging Science and Photochemistry, 2016, 34(3): 233-244.

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