Preparation of Diblock Copolymer Nano-objects by Aqueous Photoinitiated Polymerization-induced Self-assembly

doi:10.7517/j.issn.1674-0475.2017.05.005

Abstract

Abstract:

Poly(glycerol monomethacrylate) (PGMA) and sodium phenyl-2,4,6-tri-methylbenzoylphosphinate (SPTP) were used as macro-RAFT agent and initiator, respectively. A series of poly(glycerol monomethacrylate)-b-poly (2-hydroxypropyl methacrylate) (PGMA-b-PHPMA) diblock copolymer nano-objects were prepared by aqueous visible light-mediated RAFT dispersion polymerization of HPMA. The kinetic of PISA was investigated, and a remarkably diverse set of complex morphologies (spheres, worms, and vesicles) have been prepared by aqueous photo-PISA under mild conditions (water medium, visible light, and room temperature), then the effect of reaction conditions on the morphology of nano-objects was investigated. The polymerization can be activated or deactivated by a simple "ON/OFF" switch of the light source.

Key words: photoinitiation, polymerization-induced self-assembly, RAFT polymerization, block copolymer

BAI Yuhao, TAN Jianbo, ZHANG Li. Preparation of Diblock Copolymer Nano-objects by Aqueous Photoinitiated Polymerization-induced Self-assembly[J]. Imaging Science and Photochemistry, 2017, 35(6): 816-823.

References

[1] Mai Y, Eisenberg A. Self-assembly of block copolymers[J]. Chemical Society Reviews, 2012, 41(41):5969-5985.
[2] Lee J S, Feijen J. Polymersomes for drug delivery:design, formation and characterization[J]. Journal of Controlled Release, 2011, 161(2):473-483.
[3] 钟克利, 尹炳柱, 金龙一. 胶束作为纳米反应器的研究进展[J]. 高分子通报, 2009, (2):48-57. Zhong K L, Yin B Z, Jin L Y. Progress in study of micelle as nanoreactor[J]. Chinese Polymer Bulletin, 2009, (2):48-57.
[4] Wang Z, vanOers M C, Rutjes F P,van Hest J C. Polymersome colloidosomes for enzyme catalysis in a biphasic system[J]. Angewandte Chemie International Edition, 2012, 51(43):10746-10750.
[5] Tian J, Chen H, Zhuo L, Xie Y, Li N, Tang B. A highly selective, cell-permeable fluorescent nanoprobe for ratiometric detection and imaging of peroxynitrite in living cells[J]. Chemistry-A European Journal, 2011, 17(24):6626-6634.
[6] Ning Y, Fielding L A, Andrews T S,Growney D J,Armes S P. Sulfate-based anionic diblock copolymer nanoparticles for efficient occlusion within zinc oxide[J]. Nanoscale, 2015, 7(15):6691-6702.
[7] Du J Z, Tang Y Q, Lewis A L, Armes S P. pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer[J]. Journal of the American Chemical Society, 2005, 127(51):17982-17983.
[8] Kita-Tokarczyk K, Grumelard J, Haefele T, Meier W. Block copolymer vesicles-using concepts from polymer chemistry to mimic biomembranes[J]. Polymer, 2005, 46(11):3540-3563.
[9] 费晨洪, 王伟, 冯玉军. 嵌段聚合物PGMA-b-PDEAEMAx的合成及其CO₂诱导解组装行为[J]. 合成化学, 2014, 22(6):734-738. Fei C H, Wang W, Feng Y J. Synthesis and CO₂-induced disassembly of diblock copolymers PGMA-b-PDEAEMAx[J]. Chinese Journal of Synthetic Chemistry, 2014, 22(6):734-738.
[10] Sun J T, Hong C Y, Pan C Y. Recent advances in RAFT dispersion polymerization for preparation of block copolymer aggregates[J]. PolymChem, 2013, 4(4):873-881.
[11] Rieger J. Guidelines for the synthesis of block copolymer particles of various morphologies by RAFT dispersion polymerization[J]. Macromolecular Rapid Communications, 2015, 36(16):1458-1471.
[12] Fielding L A, Derry M J, Ladmiral V, Rosselgong J, Rodrigues A M, Ratcliffe L P D, Sugiharaef S, Armes S P. RAFT dispersion polymerization in non-polar solvents:facile production of block copolymer spheres, worms and vesicles in n-alkanes[J]. Chemical Science, 2013, 4(5):2081-2087.
[13] Lopezoliva A P, Warren N J, Rajkumar A, Mykhaylyk O O, Derry M J, Doncom K E B, Rymaruk M J, Armes S P. Polydimethylsiloxane-based diblock copolymer nano-objects prepared in nonpolar media via RAFT-mediated polymerization-induced self-assembly[J]. Macromolecules, 2015, 48(11):3547-3555.
[14] Blanazs A, Ryan A J, Armes S P. Predictive phase diagrams for RAFT aqueous dispersion polymerization:effect of block copolymer composition, molecular weight, and copolymer concentration[J]. Macromolecules, 2012, 45(12):5099-5107.
[15] Hill M R, Carmean R N, Sumerlin B S. Expanding the scope of RAFT polymerization:recent advances and new horizons[J]. Macromolecules, 2015, 48(16):5459-5469.
[16] Sugihara S, Blanazs A, Armes S P, Ryan A J, Lewis A L. Aqueous dispersion polymerization:a new paradigm for in situ block copolymer self-assembly in concentrated solution[J]. Journal of the American Chemical Society, 2011, 133(39):15707-15713.
[17] Liu G, Qian Q, Shen W, An Z. Aqueous dispersion polymerization of 2-methoxyethyl acrylate for the synthesis of biocompatible nanoparticles using a hydrophilic RAFT polymer and a redox initiator[J]. Macromolecules, 2011, 44(44):5237-5245.
[18] Zhou W, Qu Q, Xu Y, An Z. Aqueous polymerization-induced self-assembly for the synthesis of ketone-functiona-lized nano-objects with low polydispersity[J]. Acs Macro Letters, 2015, 4(5):495-499.
[19] Chambon P, Blanazs A, Battaglia G, Armes S P. Facile synthesis of methacrylic ABC triblock copolymer vesicles by RAFT aqueous dispersion polymerization[J]. Macromolecules, 2012, 45(12):5081-5090.
[20] Ratcliffe L P D, Ryan A J, Armes S P. From a Water-immiscible monomer to block copolymer nano-objects via a one-pot RAFT aqueous dispersion polymerization formulation[J]. Macromolecules, 2013, 46(3):769-777.
[21] Warren N J, Mykhaylyk O O, Mahmood D, Ryan A, Armes S P. RAFT aqueous dispersion polymerization yields poly(ethyleneglycol)-based diblock copolymer nano-objects with predictable single phase morphologies[J]. Journal of the American Chemical Society, 2014, 136(3):1023-1033.
[22] Figg C A, Simula A, Gebre K A, Tucker B S, Haddleton D M, Sumerlin B S. Polymerization-induced thermal self-assembly (PITSA)[J]. Chemical Science, 2014, 6(2):63-80.
[23] Moad G, Chong Y K, Postma A, Rizzardo E, Thang S H. Advances in RAFT polymerization:the synthesis of polymers with defined end-groups[J]. Polymer, 2005, 46(19):8458-8468.
[24] Jiang Y, Xu N, Han J, Cai Y L. Direct synthesis of interface-decorated reactive block copolymer nanoparticles via polymerisation-induced self-assembly[J]. Polymer Chemistry, 2015, 6(27):4955-4965.