The Value of Bedside Cranial Ultrasound Combined with Amplitude-integrated Electroencephalogram in the Assessment of Brain Function and Development of Premature Infants

doi:10.7517/issn.1674-0475.191112

Abstract

Abstract: To investigate the effect of bedside cranial ultrasound combined with amplitude-integrated electroencephalogram (aEEG) on the development of brain function in preterm infants, 100 premature infants were selected on NICU from June 2017 to April 2019, in this study. According to the clinical diagnosis of brain injury, the children were divided into brain injury group (42 cases) and non brain injury group (58 cases). Two groups of children were given bedside cranial ultrasound and aEEG examination.The changes of amplitude voltage of AS and QS were compared between the two groups. To draw ROC curve and analyze the diagnostic efficacy of bedside cranial ultrasound, aEEG and their joint examination on brain injury of premature infants. The results show that, the abnormal rate of ultrasonic examination and the abnormal detection rate of amplitude in brain injury group were significantly higher than those in non brain injury group (P<0.05). The continuous voltage, the periodic detection rate of sleep and the amplitude voltage of AS and QS in brain injury group were significantly lower than those in non brain injury group (P<0.05). ROC curve analysis showed that, the sensitivity and specificity of bedside cranial ultrasound combined with aEEG were significantly higher than that of single examination (P<0.05). Therefore, bedside brain ultrasound can reflect the development status of brain parenchyma and aEEG can reflect the development status of brain function of preterm infants. The combined examination has a better effect for evaluation the brain injury of premature infants.

Key words: premature infant, bedside cranial ultrasound, amplitude-integrated electroencephalogram (aEEG), brain development, brain injury

LI Juhua, YANG Xinchen. The Value of Bedside Cranial Ultrasound Combined with Amplitude-integrated Electroencephalogram in the Assessment of Brain Function and Development of Premature Infants[J]. Imaging Science and Photochemistry, 2020, 38(3): 482-486.

References

[1] 王月怡,沈文莉,高彩云,等.振幅整合脑电图在新生儿缺氧缺血性脑病早期诊治及预测预后中的应用价值[J].临床和实验医学杂志,2017,16(12):1227-1230. Wang Y Y, Shen W L, Gao C Y, et al.Value of amplitude integrated electroencephalogram in early diagnosis, treatment and prognosis of hypoxic-ischemic encephalopathy[J]. Journal of Clinical and Experimental Medicine, 2017,16(12):1227-1230.
[2] 沈佩婷,黄金华,温晓红, 等.振幅整合脑电图对早产儿脑白质损伤的早期诊断及近期神经发育预后评估的应用价值[J].中国妇幼保健,2019,34(4):942-945. Shen P T, Huang J H, Wen X H, et al.The value of amplitude integrated electroencephalogram in the early diagnosis of brain white matter injury in premature infants and the evaluation of the prognosis of neural development in the near future[J]. China Maternal and Child Health Care, 2019,34(4):942-945.
[3] Middel R G, Brandenbarg N, Van Braeckel K N J A, et al.The predictive value of amplitudeintegrated electroencephalography in preterm infants for IQ and other neuropsychological outcomes at early school age[J]. Neonatology, 2018,113(4):287-295.
[4] 洪菲,叶蕾,徐明.振幅整合脑电图在新生儿缺氧缺血性脑病中的应用价值[J].现代中西医结合杂志,2017,26(9):1008-1010. Hong F, Ye L, Xu M. The application value of amplitude integrated EEG in neonatal hypoxic-ischemic encephalopathy[J]. Journal of Modern Integrated Chinese and Western Medicine, 2017,26(9):1008-1010.
[5] 张红琴,赵月乔.振幅整合脑电图对宫内窘迫新生儿病情严重程度的早期评估价值[J].中国妇幼保健,2018,33(4):938-941. Zhang H Q, Zhao Y Q. Value of amplitude integrated EEG in early assessment of the severity of intrauterine distress in neonates[J]. China Maternal and Child Health Care, 2018,33(4):938-941.
[6] 丛晓亚,蔡芙莺,胡旻婧, 等.振幅整合脑电图联合婴儿智能发育量表在早产儿脑损伤中的诊断价值[J].江苏医药,2017,43(16):1143-1146. Cong X Y, Cai F Y, Hu M J, et al.Diagnostic value of amplitude integrated electroencephalogram and infant intelligence development scale in brain injury of premature infants[J]. Jiangsu Medical Journal, 2017,43(16):1143-1146.
[7] 秦璇,姜泓.振幅整合脑电图在新生儿脑损伤中的应用进展[J].中国综合临床,2018,34(3):284-288. Qin X, Jiang H. Progress in the application of amplitude integrated electroencephalogram in neonatal brain injury[J]. China Integrated Clinical, 2018,34(3):284-288.
[8] Czyzewski A, Kostek B. Assessment of hearing in coma patients employing auditory brainstem response, electroencephalography, and eyegazetracking[J]. Journal of the Acoustical Society of America, 2017,141(5):3903-3904.
[9] 万鑫,侯梅,刘志翠.早产脑瘫病儿伴发癫痫和脑电放电模式的特征及其危险因素分析[J].精准医学杂志,2018,158(2):80-83. Wan X, Hou M, Liu Z C. Analysis of characteristics and risk factors of epilepsy and EEG discharge patterns in preterm children with cerebral palsy[J]. Journal of Precision Medicine, 2018, 158(2):80-83.
[10] 刘辉娟,刘晶莹,花媛媛, 等.振幅整合脑电图在亚低温治疗新生儿缺氧缺血性脑病中的应用[J].中华实用儿科临床杂志,2017,32(2):143-145. Liu H J, Liu J Y, Hua Y Y, et al.Application of amplitude integrated electroencephalogram in the treatment of neonatal hypoxic-ischemic encephalopathy with mild hypothermia[J]. Chinese Journal of Practical Pediatrics, 2017,32(2):143-145.
[11] 黄云倩,吴晓萍,周先举.振幅整合脑电图联合全身运动质量评估在预测高危新生儿神经发育结局中的应用价值[J].实用医院临床杂志,2018,15(5):174-177. Huang Y Q, Wu X P, Zhou X J. The application value of amplitude integrated electroencephalogram (aEEG) combined with general motor quality assessment in predicting neurodevelopmental outcome of high-risk neonates[J]. Journal of Clinical Practice Hospital, 2018,15(5):174-177.
[12] Weeke L C, Vilan A, Toet M C, et al.A Comparison of the thompson encephalopathy score and amplitude-integrated electroencephalography in Infants with perinatal asphyxia and therapeutic hypothermia[J]. Neonatology, 2017,112(1):24-29.
[13] 邱锐琴,吴小波,夏明月, 等.新生儿振幅整合脑电图对评估早产儿脑功能发育状态的临床应用价值[J].河北医学,2019,25(4):617-622. Qiu R Q, Wu X B, Xia M Y, et al.The clinical value of amplitude integrated electroencephalogram in the assessment of brain function and development of premature infants[J]. Hebei Medical Journal, 2019,25(4):617-622.
[14] 张树英,曾贵祥,陈海华, 等.振幅脑电图联合头颅超声检查预测超低或极低出生体重早产儿神经系统发育结局的效果[J].广西医学,2018,40(16):1889-1891. Zhang S Y, Zeng G X, Chen H H, et al.The effect of amplitude electroencephalogram combined with cranial ultrasound on predicting the outcome of nervous system development in very low or very low birth weight premature infants[J]. Guangxi Medical Journal, 2018,40(16):1889-1891.
[15] 陈丽霞,章旭平,徐文慧, 等.床旁B超结合振幅整合脑电图在早产儿脑发育脑损伤评估中的应用价值研究[J].江西医药,2019,54(7):796-798. Chen L X, Zhang X P, Xu W H, et al.Study on the application value of bedside B ultrasound combined with amplitude integrated electroencephalogram in the assessment of brain development and brain injury in preterm infants[J]. Jiangxi Medical Journal, 2019,54(7):796-798.