SYNTHESIS OF PHOSPHATIDIC ACID ANALOGUE FOR PHOTOAFFINITY LABELING

doi:10.7517/j.issn.1674-0475.2003.03.195

Abstract

Abstract: Phosphatidic acid(PA)analogue for photoaffinity labeling was synthesized,which beats the photoactivable group on the sn 1 fatty acyl chain.The perfluorophenyl azide was selected as photoactivable group for it gaving more C-H insertion than that of nonfluorinated analogues.Isotope ³³P was introduced into the PA analogue by enzymatic method.Primary test showed that the PA analogue was as efficient as naturally occurring PA in activating cAMP phosphodiesterases,suggesting that it could be proper candidate for farther enzymatic photoaffinity labeling.

Key words: photoaffinity labeling, phosphatidic acid, synthesis

CLC Number:

HUANG Yan, XU Lan-qin . SYNTHESIS OF PHOSPHATIDIC ACID ANALOGUE FOR PHOTOAFFINITY LABELING[J]. Imaging Science and Photochemistry, 2003, 21(3): 195-199.

[1]	ZHU Tao, ZHANG Yan, DONG Lulu, GUO Pengyue, YANG Dongzhi. Biomimetic Synthesis of Au QDs and the Application of Glucose Detection in Serum [J]. Imaging Science and Photochemistry, 2020, 38(6): 941-949.
[2]	TAO Pingfang, FENG Yuqin, ZHOU Neng, QIN Liqin, ZHANG Pei. Hydrothermal Synthesis of α-NaYF₄: Ce³⁺/Tb³⁺ Nanospheres with High Fluorescence Properties [J]. Imaging Science and Photochemistry, 2018, 36(2): 161-170.
[3]	JI Haixia, DONG Lulu, DU Yan, YAO Xinyue, YANG Dongzhi. Biomimetic Synthesis of CdS Quantum Dots in Living Cancer Cells [J]. Imaging Science and Photochemistry, 2018, 36(1): 57-63.
[4]	ZENG Ze, ZHONG Rong, ZHANG Chunhui, XIE Gang. Synthesis and Properties of Phenylglyoxylic Acid Ester/2959 Photoinitiator [J]. Imaging Science and Photochemistry, 2017, 35(6): 808-815.
[5]	DENG Yafeng, ZHOU Yihua, QIAN Jun, LUO Yan, WU Lihui. Preparation and Application of Carbon Quantum Dots Based on Up Conversion Photoluminescence [J]. Imaging Science and Photochemistry, 2017, 35(6): 884-893.
[6]	WANG Hua. Chemical and Photochemical Synthesis of Thiophene-based Helicenes [J]. Imaging Science and Photochemistry, 2017, 35(5): 603-613.
[7]	ZHANG Qingbao, LIU Qiang. Applications of Visible-light-driven Aerobic Oxidation in Organic Synthesis [J]. Imaging Science and Photochemistry, 2017, 35(5): 614-625.
[8]	CAO Yitao, WU Lizhu, TONG Zhenhe(TUNG Chenho), ZHANG Tierui. Photochemical Synthesis of Inorganic Nanomaterials [J]. Imaging Science and Photochemistry, 2017, 35(5): 642-648.
[9]	GUI Mengxi, YU Yang, ZHU Chengyi, LIU Hongfang, WANG Feng. Advances on Molecular Systems for Photocatalytic CO₂ Reduction Based on Cobalt Complexes as Catalysts [J]. Imaging Science and Photochemistry, 2017, 35(5): 649-657.
[10]	LEI Yuan, ZHANG Sai, GAO Jun. Synthesis,Structure and Photochromic Properties of N-ethyl-9'-n Bromobutoxy Spirooxazine and Its Modified PMMA [J]. Imaging Science and Photochemistry, 2016, 34(6): 526-533.
[11]	JIANG Wei, WU Xiang. Hydrothermal Synthesis and Photocatalytic Properties of ZnS Microflowers [J]. Imaging Science and Photochemistry, 2016, 34(3): 252-256.
[12]	YANG Ke, ZHANG Yan, XU Jianhua. The Application of Electron Transfer Photo-oxidation Reaction in Organic Synthesis [J]. Imaging Science and Photochemistry, 2014, 32(5): 433-446.
[13]	LI Bing, XIA Wujiong. Solid-state Asymmetric Photochemistry of Bicyclo[3.1.0] hexyl Ketone Carbonyl Derivatives [J]. Imaging Science and Photochemistry, 2014, 32(5): 455-462.
[14]	LIANG Qinghua, SHI Yao, MA Wangjing, YANG Xinmin, LI Zhi. Hydrothermal Synthesis and Characterization of Ba₇F₁₂Cl₂：Eu²⁺ Used for X-ray Imaging Plate [J]. Imaging Science and Photochemistry, 2014, 32(2): 150-156.
[15]	LI Bo, HUANG Zhongbing, MENG Xianwei, TANG Fangqiong. Hydrothermal Synthesis and Application of the Fe₃O₄ Nanoparticles Modified with L-cysteine [J]. Imaging Science and Photochemistry, 2014, 32(2): 163-170.

SYNTHESIS OF PHOSPHATIDIC ACID ANALOGUE FOR PHOTOAFFINITY LABELING

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments