超声造影增强特征和定量参数鉴别甲状腺微小乳头癌的效能及与生物学行为的关系研究

doi:10.7517/issn.1674-0475.201201

摘要/Abstract

摘要： 本研究选取了甲状腺微小乳头癌患者68例作为研究组，甲状腺良性小结节患者65例作为对照组，探究了超声造影增强特征和定量参数在鉴别甲状腺微小乳头癌与良性小结节中的应用价值及与其生物学行为的关系。其中研究组超声造影增强特征以早期低增强或低增强为主，对照组以等增强或高增强为主，两组超声造影增强特征对比，差异有统计学意义（P<0.05）。研究组PI低于对照组，TTP长于对照组（P<0.05）。超声造影增强特征、PI、TTP联合诊断甲状腺微小乳头癌的曲线下面积（AUC）为0.896，大于各指标单独诊断。甲状腺微小乳头癌肿瘤直径、腺外浸润、淋巴结转移与超声造影增强程度、PI呈负相关，与TTP呈正相关；分化程度与超声造影增强程度、PI呈正相关，与TTP呈负相关（P<0.05）。由以上结果可知，超声造影增强特征和定量参数PI、TTP在甲状腺微小乳头癌诊断方面具有较高效能，且与其生物学行为间存在密切相关性。

关键词: 甲状腺微小乳头癌, 甲状腺良性小结节, 超声造影, 鉴别诊断, 肿瘤生物学行为

Abstract: In this paper, the application value of the enhancement feature and quantitative parameters of contrast-enhanced ultrasound in the identification for papillary thyroid carcinoma and benign nodules were explored, as well as their relationship with biological behaviors of the thyroid carcinoma. There were 68 patients with papillary thyroid carcinoma who were selected as the study group, and 65 patients with benign thyroid nodules who were selected as the control group. The contrast enhancement features of the study group were mainly low enhancement in the early stage or in the whole stage, and in the control group was mainly equal or high enhancement. There was a statistically significant difference in enhancement characteristics of contrast-enhanced ultrasound between the two groups (P<0.05). The PI of the study group was lower than that of the control group, and the TTP was longer than the control group (P<0.05). The area under the curve (AUC) of the combined diagnosis for thyroid micropapillary carcinoma by contrast-enhanced ultrasound, PI, and TTP was 0.896, which was greater than that of each index alone. Tumor diameter, extraglandular invasion and lymph node metastasis of thyroid micropapillary carcinoma were negatively correlated with the enhanced degree of contrast-enhanced ultrasound and PI, and positively correlated with TTP. The degree of 422 differentiation was positively correlated with the enhanced degree of contrast-enhanced ultrasound and PI, and negatively correlated with TTP (P<0.05). In conclusion, contrast-enhanced ultrasound features and quantitative parameters (PI and TTP) have high diagnostic efficiency in the diagnosis of thyroid micropapillary carcinoma, and has a close correlation with the biological behavior of cancer.

Key words: thyroid micropapillary carcinoma, benign thyroid nodules, contrast-enhanced ultrasound, differential diagnosis, tumor biological behavior

张倩, 邱爽, 邓小倩, 张博学, 高净, 刘晓玲. 超声造影增强特征和定量参数鉴别甲状腺微小乳头癌的效能及与生物学行为的关系研究[J]. 影像科学与光化学, 2021, 39(3): 422-427.

ZHANG Qian, QIU Shuang, DENG Xiaoqian, ZHANG Boxue, GAO Jing, LIU Xiaoling. Study on the Efficacy of Enhanced Features and Quantitative Parameters of Contrast-enhanced Ultrasound in Identifying Papillary Thyroid Carcinoma and the Relationship with Biological Behavior[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(3): 422-427.

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