关键词: 帕金森病, 磁共振定量磁敏感图, 黑质磁敏感值, 红核磁敏感值, 病情程度, 近期预后

Abstract: In order to explore the relationship between the substantia nigra, red nucleus susceptibility value of quantitative susceptibility imaging and the degree of Parkinson’s disease (PD) and the value of predicting the short-term prognosis, fifty-four patients with PD were selected as the research object, and they were divided into a good prognosis group based on the recent prognosis (39 cases) and poor prognosis group (15 cases). The results showed that the substantia nigra and red nucleus susceptibility values of the poor prognosis group were higher than those of the good prognosis group (P<0.05); the substantia nigra and red nucleus susceptibility values of patients with stage Ⅳ-Ⅴ were higher than those of stage Ⅲ, Ⅰ-Ⅱ, and stage Ⅲ patients higher than that in patients with stage Ⅰ to Ⅱ (P<0.05); there is a positive correlation between the substantia nigra and red nucleus susceptibility values and the severity of the disease (P<0.05); the substantia nigra and red nucleus susceptibility values are still significantly related to the short-term prognosis of PD patients (P<0.05). The area under the curve (AUC) of substantia nigra and red nucleus susceptibility predicting poor prognosis of PD were 0.708 and 0.678, respectively, and the combined predicted AUC was the largest, which was 0.846. Based on this, it can be seen that the magnetic susceptibility values of the substantia nigra and red nuclei are positively correlated with the severity of PD. Quantitative magnetic susceptibility imaging measurement has high application value in predicting the short-term prognosis of PD.258

Key words: Parkinson’s disease, magnetic resonance quantitative susceptibility map, substantia nigra susceptibility value, red nucleus susceptibility value, disease severity, short-term prognosis