关键词: 带状疱疹, 神经痛, 静息态功能磁共振成像, 脑功能分区

Abstract: This study explored the clinical value of magnetic resonance imaging (MRI) in patients with post-herpetic neuralgia (PHN) in assessing brain functional divisions and gray matter volume changes. Thirty-four patients with PHN (PHN group) and 40 healthy volunteers (control group) were selected as the research subjects. They received resting state functional magnetic resonance imaging (rs-FMRI), and the differences in low-frequency amplitude values between the PHN group and the control group were compared. The results showed that the low-frequency amplitude values of the PHN group in the brain stem, left and right temporal lobes, left and right frontal lobes, right anterior cingulate gyrus, and right parietal lobe were higher than those in the control group (P<0.05). The low-frequency amplitude values of PHN group had left and right insula, middle frontal gyrus, left and right central anterior gyrus, right hippocampus, and right fusiform gyrus were significantly lower than those of the control group (P<0.05). The amplitude increases of low-frequency in brain stem, left and right temporal lobes, left and right frontal lobes, and right cingulate gyrus and left parietal lobe of PHN patients were positively correlated with the VAS score. Low-frequency amplitude reduction values of left and right insula, middle frontal gyrus, left and right central anterior gyrus, right para 286 hippocampal gyrus, and right fusiform gyrus were negatively correlated with the VAS score. In the resting state, the brain functional areas of PHN patients changed compared with the normal population, which may be related to the increased pain perception level of the patients.

Key words: herpes zoster, neuralgia, resting functional magnetic resonance imaging, brain function division