喹啉氧基酞菁金属配合物光敏化氧化色氨酸能力的研究

doi:10.7517/j.issn.1674-0475.2012.02.124

影像科学与光化学 ›› 2012, Vol. 30 ›› Issue (2): 124-128.DOI: 10.7517/j.issn.1674-0475.2012.02.124

喹啉氧基酞菁金属配合物光敏化氧化色氨酸能力的研究

刘宏, 郑科, 李俊, 蔡丽璇, 方昱婷, 薛金萍

福州大学化学化工学院, 福建福州 350002

收稿日期:2011-10-26 修回日期:2011-12-19 出版日期:2012-03-15 发布日期:2012-03-15
通讯作者: 薛金萍,教授,E-mail:xuejinping66@yahoo.com.cn.
基金资助:
国家科技部科技重大专项(2011ZX09101-001-04);福建省科技厅重大项目(2009Y2004).

Study on Photosensitive Oxidation Ability of Metallophthalocyanines on Tryptophan

LIU Hong, ZHENG Ke, LI Jun, CAI Li-xuan, FANG Yu-ting, XUE Jin-ping

College of Chemistry and Chemical Engineering, Fuzhou University, Fuzhou 350002, Fujian, P.R.China

Received:2011-10-26 Revised:2011-12-19 Online:2012-03-15 Published:2012-03-15

摘要/Abstract

摘要： 酞菁金属配合物是光动力治疗的新一代光敏剂,其治疗作用的机理以及引起的生物效应一直是人们研究的热点.本文选用色氨酸作为与喹啉氧基酞菁金属配合物作用的靶分子,讨论了配合物的组成结构与其光敏化氧化色氨酸能力的相关性.结果表明,酞菁环内中心金属离子和环周边取代基的组成结构以及取代位置与数目都影响其光敏化氧化色氨酸能力,中心金属离子为闭壳层电子结构、取代基位于α位以及提高取代基数目均有利于提高光敏化氧化活性,同时显示,取代基的组成结构对靶分子有一定选择性,研究结果可为研发该类光敏剂提供依据.

关键词: 喹啉氧基, 酞菁金属配合物, 色氨酸, 光敏化氧化

Abstract: Phthalocyanines are promising photosensitizers for application in PDT. The mechanism of the therapeutic and biological effects induced by them has been the hot topic of research on PDT. Tryptophan was choosed as a target molecule which reacted with metallophthalocyanines substituted with quinolinoxy groups, to discuss the relationship between structure and photosensitive oxidation ability. The results show that photo-oxidizing ability of phthalocyanines was influenced by the central metal ion, the structure of substitutional group, the substituent position and the number of substitutional group. Phthalocyanines with closed-shell electronic structure central metallic ion, rich substituents and substituted in α position, exibit higher photosensitive oxidation ability. This study can offer some guidance for the design of new photosensitizers.

Key words: quinolinoxy, metallophthalocyanines, photosensitive oxidation, tryptophan

中图分类号:

O611
O614

刘宏, 郑科, 李俊, 蔡丽璇, 方昱婷, 薛金萍. 喹啉氧基酞菁金属配合物光敏化氧化色氨酸能力的研究[J]. 影像科学与光化学, 2012, 30(2): 124-128.

LIU Hong, ZHENG Ke, LI Jun, CAI Li-xuan, FANG Yu-ting, XUE Jin-ping. Study on Photosensitive Oxidation Ability of Metallophthalocyanines on Tryptophan[J]. Imaging Science and Photochemistry, 2012, 30(2): 124-128.

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喹啉氧基酞菁金属配合物光敏化氧化色氨酸能力的研究

Study on Photosensitive Oxidation Ability of Metallophthalocyanines on Tryptophan

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