刺激响应型微胶囊的可控释放研究进展

doi:10.7517/j.issn.1674-0475.2015.02.168

摘要/Abstract

摘要：

刺激响应型微胶囊由于具有独有的高稳定性、多功能性、膜结构的可调性、以及对不同芯材的运送能力,在药物封装和释放、人造细胞、催化、化学传感器等领域具有广阔的应用前景.本文综述了近年来不同刺激响应型复合微胶囊的可控释放的研究进展,包括温敏型、pH响应型、磁响应型、生物响应型、电响应型,以及光响应型微胶囊,根据释放机理的不同着重对光响应型微胶囊的释放过程进行了总结,并对微胶囊可控释放在未来的发展趋势进行了展望.

关键词: 刺激响应型, 微胶囊, 药物传输, 可控释放

Abstract:

Owing to their unique properties such as high stability, versatility, tunable membrane properties, and capability of delivering a variety of core substances, stimuli-responsive microcapsules have been applied to a wide range of areas, including drug encapsulation and release, artificial cells, catalysis, and chemical sensors. This review focused on the development of various types of stimuli-responsive microcapsules, including thermo-responsive, pH-responsive, magnetic-responsive, biological-responsive, electro-responsive, and light-responsive microcapsules in the area of controlled release application, among which the release process of light-responsive microcapsules was especially emphasized. Finally, the future prospects of the controlled release of microcapsules were discussed.

Key words: stimuli-responsive, microcapsule, drug delivery, controlled release

姜涛, 胡亚楠, 龙玥, 宋恺. 刺激响应型微胶囊的可控释放研究进展[J]. 影像科学与光化学, 2015, 33(2): 168-176.

JIANG Tao, HU Yanan, LONG Yue, SONG Kai. Recent Progress on the Controlled Release of Stimuli-responsive Microcapsules[J]. Imaging Science and Photochemistry, 2015, 33(2): 168-176.

参考文献

[1] Skirtach A G, Javier A M, Kreft O, Köhler K, Alberola A P, Möhwald H, Parak W J, Sukhorukov G B. Laser-induced release of encapsulated materials inside living cells[J]. Angewandte Chemie International Edition, 2006, 45(28): 4612-4617.
[2] Peters R J R W, Louzao I, Hest J C M V. From polymeric nanoreactors to artificial organelles[J]. Chemical Science, 2012,3(2): 335-342.
[3] Zhang Q, Tiefenbacher K. Hexameric resorcinarene capsule is a bronsted acid: investigation and application to synthesis and catalysis[J]. Journal of the American Chemical Society, 2013, 135(43): 16213-16219.
[4] Amali A J, Awwad N H, Rana R K, Patra D. Nanoparticle assembled microcapsules for application as pH and ammonia sensor[J]. Analytica Chimica Acta, 2011, 708(1-2): 75-83.
[5] Zou S W, Hu Y, Wang C Y. One-pot fabrication of rattle-like capsules with multicores by pickering-based polymerization with nanoparticle nucleation[J]. Macromolecular Rapid Communications, 2014, 35(16): 1414-1418.
[6] Yin W S, Yates M Z. Effect of interfacial energy on the formation of polymer microcapsules by emulsification/free drying[J]. Langmuir, 2008, 24(3): 701-708.
[7] Wei Y, Wang Y X, Wang L Y, Hao D X, Ma G H. Fabrication strategy for amphiphilic microcapsules with narrow size distribution by premix membrane emulsification[J]. Colloids and Surfaces B: Biointerfaces, 2011, 87(2): 399-408.
[8] Volodkin D V, Petrov A I, Prevot M, Sukhorukov G B. Matrix Polyelectrolyte Microcapsules: new system for macromolecule encapsulation[J]. Langmuir, 2004, 20(8): 3398-3406.
[9] Shum H C, Kim J W, Weitz D A. Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability[J]. Journal of the American Chemical Society, 2008, 130(29): 9543-9549.
[10] Kwon O S, Jang J, Bae J. A review of fabrication methods and applications of novel tailored microcapsules[J]. Current Organic Chemistry, 2013, 17(1): 3-13.
[11] 王安河, 白振宇, 崔岳, 李峻柏.环境多响应性微胶囊的制备[J].东南大学学报(医学版), 2011, 30(1): 33-39. Wang A H, Bai Z Y, Cui Y, Li J B. Synthesis of environmental multi-responsive microcapsules[J]. Journal of Southeast University(Medical Science Edition), 2011, 30(1):33-39.
[12] Cui J W, Koeverden M P, M llner M, Kempe K, Caruso F. Emerging methods for the fabrication of polymer capsules[J]. Advances in Colloid and Interface Science, 2014, 207(SI):14-31.
[13] Liu L, Wang W, Ju X J, Xie R, Xie L Y. Smart thermo-triggered squirting capsules for nanoparticle delivery[J]. Soft Matter, 2010,6(16): 3759-3763.
[14] Fundueanu G, Constantin M, Ascenzi P, Simionescu B C. An intelligent multicompartmental system based on thermo-sensitive starch microspheres for temperature-controlled release of drugs[J]. Biomedical Microdevices, 2010, 12(4): 693-704.
[15] ?ejková J, Hanuš J, Štěpánek F. Investigation of internal microstructure and thermo-responsive properties of composite PNIPAM/silica microcapsules[J]. Journal of Colloid and Interface Science, 2010, 346(2): 352-360.
[16] Kim B, Lee H S, Kim J, Kim S H. Microfluidic fabrication of photo-responsive hydrogel capsules[J]. 2013, 49(18): 1865-1867.
[17] Sankaranarayanan J, Mahmoud, E A, Kim G, Morachis J M, Almutairi A. Multiresponse strategies to modulate burst degradation and release from nanoparticles[J]. ACS Nano, 2010, 4(10): 5930-5936.
[18] Wang X, Li G Q, Wei J, Guan W W. A novel method to control microcapsule release behavior via photo-crosslink polyurethane acrylate shells[J]. Journal of Applied Polymer Science, 2009, 113(2): 1008-1016.
[19] Zhou J, Pishko M V, Lutkenhaus J L. Thermoresponsive layer-by-layer assemblies for nanoparticle-based drug delivery[J]. Langmuir, 2014, 30(20): 5903-5910.
[20] Liang K, Such G K, Johnston A P R, Zhu Z Y, Ejima H, Richardson J J, Cui J W, Caruso F. Endocytic pH-triggered degradation of nanoengineered multilayer capsules[J]. Advanced Materials, 2014, 26(12): 1901-1905.
[21] Mauser T, D jugnat C, Sukhorukov G B. Reversible pH-dependent properties of multilayer microcapsules made of weak polyelectrolytes[J]. Macromolecular Rapid Communications, 2004, 25(20): 1781-1785.
[22] Sato K, Yoshida K, Takahashi S, Anzai J. pH- and sugar-sensitive layer-by-layer films and microcapsules for drug delivery[J]. Advanced Drug Delivery Reviews, 2011, 63(9): 809-821.
[23] Broaders K E, Pastine S J, Grandhe S, Fr chet J M. J. Acid-degradable solid-walled microcapsules for pH-responsive burst-release drug delivery[J]. Chemical Communications, 2011, 47(2): 665-667.
[24] Wang Y J, Caruso F. Template synthesis of stimuli-responsive nanoporous polymer-based spheres via sequential assembly[J]. Chemistry of Materials, 2006, 18(17): 4089-4100.
[25] Kozlovskaya V, Kharlampieva E, Drachuk I, Cheng D, Tsukruk V V. Responsive microcapsule reactors based on hydrogen-bonded tannic acid layer-by-layer assemblies[J]. Soft Matter, 2010, 6(15): 3596-3608.
[26] Pasut G, Veronese F M. Polymer drug conjugation, recent achievements and general strategies[J]. Progress in Polymer Science, 2007, 32(8-9): 933-961.
[27] Lu Z H, Prouty M D, Guo Z, Golub V O, Kumar C S S R, Lvov Y M. Magnetic switch of permeability for polyelectrolyte microcapsules embedded with Co@Au nanoparticles[J]. Langmuir, 2005, 21(5): 2042-2050.
[28] Caruso F, Spasova M, Susha A, Giersig M, Caruso R A. Magnetic nanocomposite particles and hollow spheres constructed by a sequential layering approach[J]. Chemistry of Materials, 2001, 13(1): 109-116.
[29] Fang M, Grant P S, McShane M J, Sukhorukov G B, Golub V O, Lvov Y M. Magnetic bio/nanoreactor with multilayer shells of glucose oxidase and inorganic nanoparticles[J]. Langmuir, 2002, 18(16): 6338-6344.
[30] Chen Y, Chen H R, Zeng D P, Tian Y B, Chen F, Feng J W, Shi J L. Core/shell structured hollow mesoporous nanocapsules: a potential platform for simultaneous cell imaging and anticancer drug delivery[J]. ACS Nano, 2010, 4(10):6001-6013.
[31] Chen H Y, Sulejmanovic D, Moore T, Colvin D C, Qi B, Mefford O T, Gore J C, Alexis F, Hwu S J, Anker J N. Iron-loaded magnetic nanocapsules for pH-triggered drug release and MRI imaging[J]. Chemistry of Materials, 2014, 26(6): 2105-2112.
[32] Katagiri K, Nakamura M, Koumoto K. Magnetoresponsive smart capsules formed with polyelectrolytes, lipid bilayers and magnetic nanoparticles[J]. ACS Applied Materials & interfaces, 2010, 2(3): 768-773.
[33] Hu S H, Tsai C H, Liao C F, Liu D M, Chen S Y. Controlled rupture of magnetic polyelectrolyte microcapsules for drug delivery[J]. Langmuir, 2008, 24(20): 11811-11818.
[34] Wang J P, Zhao X P, Guo H L, Zheng Q. Preparation and response behavior of blue electronic ink microcapsules[J]. Optical Materials, 2008, 30(8): 1268-1272.
[35] Ma Y J, Dong W F, Hempenius M A, Möhwald H, Vancso G J. Redox-controlled molecular permeability of composite-wall microcapsules[J]. Nature Materials, 2006, 5(9):724-729.
[36] Jafari A H, Hosseini S M A, Jamalizadeh E. Investigation of smart nanocapsules containing inhibitors for corrosion protection of copper[J]. Electrochimica Acta, 2010, 55(28): 9004-9009.
[37] Caruso M M, Schelkopf S R, Jackson A C, Landry A M, Braun P V, Moore J S. Microcapsules containing suspensions of carbon nanotubes[J]. Journal of Materials Chemistry, 2009, 19(34): 6093-6096.
[38] Odom S A, Caruso M M, Finke A D, Prokup A M, Ritchey J A, Leonard J H, White S R, Sottos N R, Moore J S. Restoration of conductivity with TTF-TCNQ charge-transfer salts[J]. Advanced Functional Materials, 2010, 20(11): 1721-1727.
[39] Yun J, Im J S, Lee Y S, Bae T S, Lim Y M, Kim H I. pH and electro-responsive release behavior of MWCNT/PVA/PAAc composite microcapsules[J]. Colloids and Surfaces A, 2010, 368(1-3): 23-30.
[40] Glangchai L C, Moore M C, Shi L, Roy K. Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles[J]. Journal of Controlled Release, 2008, 125(3):263-272.
[41] Gu Z, Yan M, Hu B, Joo K I, Biswas A, Huang Y, Lu Y F, Wang P, Tang Y. Protein nanocapsule weaved with enzymatically degradable polymeric network[J]. Nano Letters, 2009, 9(12): 4533-4538.
[42] Azagarsamy M A, Sokkalingam P, Thayumanavan S. Enzyme-triggered disassembly of dendrimer-based amphiphilic nanocontainers[J]. Journal of the American Chemical Society, 2009, 131(40): 14184-14185.
[43] Viger M L, Sheng W Z, Dor K, Alhasan A H, Carling C J, Lux J, Lux C de G, Grossman M, Malinow R, Almutairi A. Near-infrared-induced heating of confined water in polymeric particles for efficient payload release[J]. ACS Nano, 2014, 8(5): 4815-4826.
[44] Matsumura A, Tsuchiya K, Torigoe K, Sakai K, Sakai H, Abe M. Photochemical control of molecular assembly formation in a catanionic surfactant system[J]. Langmuir, 2011, 27(5):1610-1617.
[45] Dube H, Ajami D, Rebek Jr. J. Photochemical control of reversible encapsulation[J]. Angewandte Chemie International Edition, 2010, 49(18): 3192-3195.
[46] Berryman O B, Sather A C, Rebek Jr J. A light controlled cavitand wall regulates guest binding[J]. Chemical Communications, 2011, 47(2): 656-658.
[47] Angelatos A S, Radt B, Caruso F. Light-responsive polyelectrolyte/gold nanoparticle microcapsules[J]. Journal of Physical Chemistry B, 2005, 109(7): 3071-3076.
[48] Skirtach A G, Dejugnat C, Braun D, Susha A S, Rogach A L, Wolfgang J P, Helmuth M, Gleb B S. The role of metal nanoparticles in remote release of encapsulated materials[J]. Nano Letters, 2005, 5(7): 1371-1377.
[49] Sershen S R, Westcott S L, Halas N J, West J L. Temperature-sensitive polymer nanoshell composites for photothermally modulated drug delivery[J]. Journal of Biomedical Materials Research, 2000, 51(3): 293-298.
[50] Katagiri K, Koumoto K, Iseya S, Sakai M, Matsuda A, Caruso F. Tunable UV-responsive organic-inorganic hybrid capsules[J]. Chemistry of Materials, 2009, 21(2): 195-197.
[51] Tao X,Li J B, M hwald H.Self-assembly,optical behavior, and permeability of a novel capsule based on an azo dye and polyelectrolytes[J]. Chemistry-A European Journal, 2004, 10(14): 3397-3403.
[52] Bédard M F, Geest B G D, Skirtach A G, M hwald H, Sukhorukov G B. Polymeric microcapsules with light responsive properties for encapsulation and release[J]. Advances in Colloid and Interface Science, 2010, 158(1-2): 2-14.
[53] Fomina N, McFearin C, Sermsakdi M, Edigin O, Almutairi A. UV and near-IR triggered release from polymeric nanoparticles[J]. Journal of the American Chemical Society, 2010, 132(28): 9540-9542.
[54] Yuan X F, Fischer K, Schärt W. Photocleavable microcapsules built from photoreactive nanospheres[J]. Langmuir, 2005, 21(20):9374-9380.
[55] Yi Q Y, Sukhorukov G B. UV light stimulated encapsulation and release by polyelectrolyte microcapsules[J]. Advances in Colloid and Interface Science, 2014, 207(S1): 280-289.
[56] Achilleos D S,Hatton T A,Vamvakaki M.Light-regulated supramolecular engineering of polymeric nanocapsules[J]. Journal of the American Chemical Society, 2011, 134(13): 5726-5729.
[57] Vogel A, Venugopalan V. Mechanisms of pulsed laser ablation of biological tissues[J]. Chemical Reviews, 2003, 103(2): 577-644.
[58] Susana C R, Markus O, Pilar R G, Carolin G, Pavlov A M, Sukhorukov G B, Parak W J. NIR-light triggered delivery of macromolecules into the cytosol[J]. Journal of Controlled Release, 2012, 159(1): 120-127.
[59] Kurapatia R, Raichur A M. Near-infrared light-responsive graphene oxide composite multilayer capsules: a novel route for remote controlled drug delivery[J]. Chemical Communications, 2013, 49(7): 734-736.