光响应细胞粘附界面

doi:10.7517/j.issn.1674-0475.2018.02.001

影像科学与光化学 ›› 2018, Vol. 36 ›› Issue (2): 117-129.DOI: 10.7517/j.issn.1674-0475.2018.02.001

光响应细胞粘附界面

郝雨薇^1,3, 刘洪亮^2,3, 王树涛^2,3

1. 中国科学院化学研究所绿色印刷院重点实验室, 北京 100190;
2. 中国科学院理化技术研究所仿生材料与界面科学院重点实验室, 北京 100190;
3. 中国科学院大学, 北京 100049

收稿日期:2017-07-06 修回日期:2017-08-28 出版日期:2018-03-15 发布日期:2018-03-15
通讯作者: 刘洪亮, 王树涛
基金资助:
国家自然科学基金项目（21425314，21434009，21404109，21421061）、北京市科学技术委员会（Z161100000116037）、科学技术部（2013YQ190467）、国家青年拔尖人才项目和中国科学院青年创新促进会项目（2016026）资助

Photo-responsive Surfaces for Cell Adhesion

HAO Yuwei^1,3, LIU Hongliang^2,3, WANG Shutao^2,3

1. Key Laboratory of Green Printing, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China;
2. CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China;
3. University of Chinese Academy of Sciences, Beijing 100049, P. R. China

Received:2017-07-06 Revised:2017-08-28 Online:2018-03-15 Published:2018-03-15

摘要/Abstract

摘要： 光响应分子的响应过程可以通过简单调控光源波长、光强度以及曝光时间进行调节，近年来基于光响应分子构建的智能界面被越来越多地应用于调控细胞粘附行为。目前，用于构筑调控细胞粘附行为的光响应智能界面的功能分子主要有偶氮苯、螺吡喃以及它们的衍生物。基于这些光响应功能分子的光致异构化，光响应智能界面会发生物理化学性质转变，进而实现可控的细胞粘附和去粘附。设计光控细胞粘附界面为研究细胞粘附、迁移以及细胞诊断提供了一种新型便捷的策略。

关键词: 光响应界面, 细胞粘附, 偶氮苯, 螺吡喃

Abstract: Responsive process of photo-responsive molecules can be modulated by external stimuli, like wave length, light intensity and exposure time. Recently, smart surfaces based on photo-responsive molecules (such as azobenzene, spiropyran and their derivatives) have been adopted to manipulate cell adhesion. Photo-isomerization of these molecules can change the physicochemical properties of surfaces, which can induce cell adhesion and detachment. Design of photo-controlled surfaces provides a novel strategy to investigate cell adhesion, migration, and diagnosis.

Key words: photo-responsive surfaces, cell adhesion, azobenzene, spiropyran

郝雨薇, 刘洪亮, 王树涛. 光响应细胞粘附界面[J]. 影像科学与光化学, 2018, 36(2): 117-129.

HAO Yuwei, LIU Hongliang, WANG Shutao. Photo-responsive Surfaces for Cell Adhesion[J]. Imaging Science and Photochemistry, 2018, 36(2): 117-129.

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光响应细胞粘附界面

Photo-responsive Surfaces for Cell Adhesion

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