能谱CT征象及能量衰减曲线对肺腺癌浸润程度的评估研究

doi:10.7517/issn.1674-0475.211217

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (3): 479-484.DOI: 10.7517/issn.1674-0475.211217

能谱CT征象及能量衰减曲线对肺腺癌浸润程度的评估研究

田学涛¹, 聂君²

1. 武汉市蔡甸区人民医院(华中科技大学协和江北医院)胸外科, 湖北武汉 430000;
2. 华中科技大学同济医学院附属协和医院胸外科, 湖北武汉 430022

收稿日期:2021-12-20 出版日期:2022-05-15 发布日期:2022-05-27

The Study of Spectral CT Signs and Energy Attenuation Curve in Evaluating the Degree of Lung Adenocarcinoma Invasion

TIAN Xuetao¹, NIE Jun²

1. Department of Thoracic, Wuhan Caidian District People's Hospital (Union Jiangbei Hospital, Huazhong University of Science and Technology), Wuhan 430000, Hubei, P. R. China;
2. Department of Crebral Surgery, Unoin Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, P. R. China

Received:2021-12-20 Online:2022-05-15 Published:2022-05-27

摘要/Abstract

摘要： 本文探究能谱CT征象、能量衰减曲线对肺腺癌浸润程度的评估价值及对手术方案的指导意义。选取110例肺腺癌患者,根据手术病理诊断肿瘤侵袭程度不同分为A组(n=62)和B组(n=48),两组术前均行能谱CT检查。研究结果显示,B组结节类型中混合GGN比例、能量衰减曲线斜率(K值)、结节最大径、水基值均高于A组(P＜0.05);BAP1阳性患者K值、结节最大径、水基值均小于BAP1阴性患者,Ki-67阳性患者K值、结节最大径、水基值均大于Ki-67阴性患者(P＜0.05);K值、结节最大径、水基值与肺腺癌组织中BAP1表达呈负相关,与Ki-67表达呈正相关(P＜0.05);混合GGN、K值、结节最大径、水基值联合评估肺腺癌浸润程度为IAC的曲线下面积(AUC)为0.856。可见能谱CT征象、能量衰减曲线在肺腺癌浸润程度评估方面具有一定价值,对术前临床选择合适手术方案具有指导意义。

关键词: 肺腺癌, 肿瘤浸润, 能谱CT, 评估价值

Abstract: This paper explored the evaluation value of energy spectrum CT signs and energy attenuation curve in the evaluation of the degree of lung adenocarcinoma invasion and the guiding significance for the surgical plan. Selected 110 patients with lung adenocarcinoma, and according the degree of tumor invasion diagnosed by surgical pathology the were differently divided into group A (n=62) and group B (n=48), the spectral CT examination was performed in both groups before operation. The results showed that the proportion of mixed GGN, the slope of energy decay curve (K value), the maximum diameter of nodules, and the water-based value of nodules in group B were higher than those in group A (P<0.05). K value, maximum diameter of nodules and water-based values of BAP1-positive patients were lower than those of BAP1-negative patients, and K value, maximum diameter of nodules and water-based values of Ki-67-positive patients were higher than those of Ki-67-negative patients (P＜0.05). K value, maximum diameter of nodules, and water-based values were negatively correlated with the expression of BAP1 in lung adenocarcinoma tissues, and positively correlated with the expression of Ki-67 (P<0.05). The area under the curve (AUC) for mixed GGN, K value, maximum diameter of nodules, and water-based values combined assessment of lung adenocarcinoma invasion as IAC was 0.856. It can be seen that energy spectral CT signs and energy attenuation curve have certain value in evaluating the degree of lung adenocarcinoma invasion, and have guiding significance for the selection of appropriate surgical plan before surgery.

Key words: lung adenocarcinoma, tumor invasion, energy spectrum CT, evaluation value

田学涛, 聂君. 能谱CT征象及能量衰减曲线对肺腺癌浸润程度的评估研究[J]. 影像科学与光化学, 2022, 40(3): 479-484.

TIAN Xuetao, NIE Jun. The Study of Spectral CT Signs and Energy Attenuation Curve in Evaluating the Degree of Lung Adenocarcinoma Invasion[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(3): 479-484.

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能谱CT征象及能量衰减曲线对肺腺癌浸润程度的评估研究

The Study of Spectral CT Signs and Energy Attenuation Curve in Evaluating the Degree of Lung Adenocarcinoma Invasion

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