基于Chirp编码激励的微型介入式超声消融方法研究

doi:10.7517/issn.1674-0475.220338

影像科学与光化学 ›› 2022, Vol. 40 ›› Issue (5): 997-1003.DOI: 10.7517/issn.1674-0475.220338

基于Chirp编码激励的微型介入式超声消融方法研究

陈贝翼^1,2, 宁传龙², 张瑞^1,2, 黄文昌^1,2, 徐杰², 邵维维², 崔崤峣²

1. 中国科学技术大学生物医学工程学院(苏州), 生命科学与医学部, 江苏苏州 215000;
2. 中国科学院苏州生物医学工程技术研究所, 江苏苏州 215163

收稿日期:2022-04-13 发布日期:2022-09-13
通讯作者: 崔崤峣
基金资助:
江苏省重点研发计划（BE2021659）、国家重点研发计划（2018YFB2000200）和苏州市科技计划项目（SZS201903）

Study on an Internal Ultrasound Therapy Method Based on the Chirp-coded Excitation

CHEN Beiyi^1,2, NING Chuanlong², ZHANG Rui^1,2, HUANG Wenchang^1,2, XU Jie², SHAO Weiwei², CUI Yaoyao²

1. School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Suzhou 215000, Jiangsu, P. R. China;
2. Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, P. R. China

Received:2022-04-13 Published:2022-09-13

摘要/Abstract

摘要： 超声消融是目前治疗肿瘤等疾病倍受关注的方法。为了在微创介入治疗情况下，尽可能扩大消融治疗区域、缩短治疗时长，文章提出一种基于Chirp编码激励的介入式超声消融方法，结合自主研制的微型化介入消融换能器和小型化Chirp编码激励电路模块，实验验证讨论了该方法的有效性。聚丙烯酰胺（PAA）仿体实验结果表明：相比于恒定频率激励方法，采用Chirp编码激励方法，可以在相同时间内扩大单次消融的有效治疗区域；在保证一定消融治疗覆盖面积的基础上，有效减少整体消融治疗时间。

关键词: 介入超声, 超声消融, 信号调制, 热效应, 空化效应

Abstract: Ultrasound ablation is a method of treating cancer and other diseases which has received a lot of attention. The paper put forward an internal ultrasound therapy method based on Chirp-coded excitation which was studied in order to expand the therapeutic area and to reduce treatment duration. The self-made experimental platform and driving system were used in phantom experiments. The results of polyacrylamide (PAA) phantom experiments showed that, compared with constant-frequency excitation, Chirp-coded excitation can expand the effective treatment area of single ablation. On the basis of ensuring the range of ablation, the overall treatment duration can be effectively reduced.

Key words: internal ultrasound, ultrasound ablation, signal modulation, thermal effect, cavitation effect

陈贝翼, 宁传龙, 张瑞, 黄文昌, 徐杰, 邵维维, 崔崤峣. 基于Chirp编码激励的微型介入式超声消融方法研究[J]. 影像科学与光化学, 2022, 40(5): 997-1003.

CHEN Beiyi, NING Chuanlong, ZHANG Rui, HUANG Wenchang, XU Jie, SHAO Weiwei, CUI Yaoyao. Study on an Internal Ultrasound Therapy Method Based on the Chirp-coded Excitation[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2022, 40(5): 997-1003.

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基于Chirp编码激励的微型介入式超声消融方法研究

Study on an Internal Ultrasound Therapy Method Based on the Chirp-coded Excitation

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