关键词: 总胆红素, 新生儿期黄疸, 苍白球, T1加权成像, 波谱成像, 肌醇, 肌酸复合物, 谷氨酸及谷氨酰胺复合物, 急性胆红素脑病

Abstract: The purpose of this study was to analyze the differences between T1-weighted image (T1WI) signal intensity, mI/Cr and Glx/Cr in the neonatal phase of jaundice infants with different levels of total bilirubin (TSB) and to investigate its diagnostic value for acute bilirubin encephalopathy (ABE). Selected 118 children with jaundice in the neonatal period and divided into three groups (mild group, moderate group, severe group) according to TSB levels. All children underwent cranial magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). At the same time, according to whether complicated with ABE, they were divided into pure jaundice group and ABE group. Compared the changes of total bile acid (TBA), T1WI signal intensity of globus pallidus, myo-inositol (mI)/creatine complex (Cr), glutamate and glutamine phthalamide complex (Glx)/creatine complex (Cr) on MRS Images between each group. The results showed that there were significant differences in T1WI signal intensity, MRS image mI/Cr, Glx/Cr in different groups, and they were significantly correlated with TSB and TBA levels and neonatal jaundice condition. The AUC of left and right globus pallidus T1WI signal intensity, MRS image mI/Cr, Glx/Cr for the diagnosis of ABE were 0.847, 0.831, 0.742 and 0.840, respectively. The T1WI signal intensity of the left and right globus pallidus, MRS image mI/Cr, Glx/Cr were positively correlated with serum TSB and TBA levels in children with neonatal jaundice, and each index has good diagnostic value for ABE and facilitates the early diagnosis and treatment of ABE.

Key words: total serum bilirubin, neonatal jaundice, globus pallidus, T1-weighted image, spectroscopic imaging, inositol, creatine complex, glutamic acid and glutamine compound, acute bilirubin encephalopathy