Evaluation of the Relationship Between MMP-9, PAF, Lp-PLA2 and Coronary Plaque Properties Based on Dual-source CT Angiography

doi:10.7517/issn.1674-0475.190913

Abstract

Abstract: Coronary atherosclerotic heart disease is one of the common diseases that threaten health. In this study, I selected 206 patients with coronary heart disease diagnosed in our hospital from February 2017 to December 2018. Among them, there were 114 patients of acute coronary syndrome(ACS group) and 92 patients of stable angina pectoris(SAP group). The plaque properties of the patients were detected by dual-source CT angiography. The concentrations of serum MMP-9, PAF and Lp-PLA2 were measured in the laboratory, and the relationship between MMP-9, PAF, Lp-PLA2 and plaque properties was analyzed. The results showed that the plaque area and eccentricity index of the patients in the ACS group were larger than those in the SAP group (P<0.05). The levels of serum MMP-9, PAF and Lp-PLA2 in the ACS group were higher than those in the SAP group (P<0.05). The proportion of vulnerable plaques in the ACS group was significantly higher than that in the SAP group (P<0.05). The levels of serum MMP-9, PAF and Lp-PLA2 in all vulnerable plaques were higher than those in stable plaques, and the difference was statistically significant (P<0.05). The eccentricity index of coronary plaque was positively correlated with serum MMP-9, PAF and Lp-PLA2 concentrations (P<0.05). Therefore, the observation of coronary atherosclerotic plaque by dual-source CT angiography and serum MMP-9, PAF and Lp-PLA2 levels can be used to assess the patient's condition. Serum MMP-9, PAF and Lp-PLA2 concentrations are related to the nature and instability of plaque, which can provide a basis for predicting the nature of coronary plaque in patients.

Key words: dual-source CT angiography, MMP-9, PAF, Lp-PLA2, coronary plaque

CLC Number:

LIU Feng, DENG Daping. Evaluation of the Relationship Between MMP-9, PAF, Lp-PLA2 and Coronary Plaque Properties Based on Dual-source CT Angiography[J]. Imaging Science and Photochemistry, 2020, 38(2): 291-295.

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