Abstract: To compare the diagnostic performance of contrast-enhanced spectral mammography(CESM) with full-field digital mammography(FFDM) in dense breast disease, a total of 137 patients with proven dense breast who visited our department of breast surgery and pathologically confirmed from March 2017 to December 2018, were retrospectively enrolled in this study. All the patients underwent both FFDM and CESM examinations within one week. Using pathology results as the gold standard, sensitivity, specificity, positive prediction value(PPV),negative prediction value(NPV) and accuracy of dense breast disease by two methods were calculated,and the diagnostic efficacy of FFDM and CESM for dense breast diseases were compared. The results showed that a total of 140 lesions were detected in 137 patients, including 105 benign lesions and 35 malignant lesions. The CESM has significantly higher specificity, PPV, and accuracy in dense breast diseases than FFDM (P<0.05). It is suggested that compared with FFDM, CESM has better diagnostic efficacy of dense breast disease.

Key words: dense breast, contrast-enhanced spectral mammography, full-field digital mammography, breast lesions