Abstract: The diagnostic efficacy of 3.0T dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined with serum free prostate specific antigen(fPSA)/total prostate specific antigen(tPSA) in prostate cancer (PCa) was explored. 180 patients suspected PCa (PCa group) and 180 cases of benign prostatic hyperplasia (BPH group) were selected, all subjects were scanned with 3.0T DCE-MRI. The volume transfer constant (K^trans), the rate constant of the contrast medium returning to the plasma from the extracellular space (K_ep) and the volume fraction of the extracellular space (V_e) were calculated. The levels of serum FPSA and TPSA were measured by enzyme-linked immunosorbent assay (ELISA), and the ratio of fPSA/tPSA were calculated. Compared with BPH group, the levels of K^trans, K_ep, fPSA and tPSA in PCa group were significantly higher (P<0.05), while fPSA/tPSA were significantly lower (P<0.05). The levels of K^trans and K_ep of PCa patients were negatively correlated with the levels of serum 871 fPSA/tPSA (P<0.05). The areas under the curve (AUC) of diagnosing PCa by combined detection was 0.961, and it was significantly better than single detection. The levels of K^trans and K_ep of DCE-MRI is correlated with the level of serum fPSA/tPSA, which can significantly improve the diagnostic efficiency of PCa and has more clinical application value.

Key words: prostate cancer, 3.0T dynamic contrast-enhanced magnetic resonance imaging, prostate specific antigen