Abstract: In this paper, we used SPECT/CT to analyze the severity degree of liver fibrosis. 124 patients were divided into fibrosis group and non-fibrosis group according to the pathological results, and classified the degree of fibrosis. The SPECT/CT quantitative analysis indexes of patients with different degrees of liver fibrosis were compared and analyzed. The results showed that the level of platelet count, LHL₁₅ and SUV_mean of liver fibrosis patients are significantly lower than those of non-fibrosis patients, which are protective factors to liver fibrosis. The level of prothrombin activity of fibrosis group is significantly higher than the non-fibrosis group, which is an independent risk factor. The AUC of SUV_mean on liver fibrosis is significantly higher than other indicators (P<0.05), and the best cut-off point is ≤ 6.48. The level of LHL₁₅ and SUV_mean in patients with S0-S1 grade liver fibrosis are significantly higher than that in patients with S2-S4 grade liver fibrosis, while the Child-Pugh score was lower than that of patients with S2-S4 grade (P<0.05). The level of SUV_mean had a significantly negative correlation with the degree of liver fibrosis (ρ=-0.873, P=0.000). The results of this experiment showed that the level of SUV_mean can evaluate the severity of liver fibrosis.

Key words: liver fibrosis, severity, SPECT/CT