Correlation Between the Quantitative Parameters of MR Diffusion Tensor Imaging and the Expression of VEGF and MMP-9 in Brain Gliomas

doi:10.7517/issn.1674-0475.200703

Abstract

Abstract: The correlation between the quantitative parameters of magnetic resonance diffusion tensor imaging (DTI) and the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase-9 (MMP-9) was analyzed in this study, as well as the diagnostic value of the parameters on pathological grade in brain gliomas. According to the pathological grade, 102 patients with brain gliomas were divided into low-grade group (47 cases) and high-grade group (55 cases). All patients were examined by MRI and DTI, through which the ADC, FA, rADC, rFA and rAD were measured. The expression of VEGF and MMP-9 were detected by immunohistochemistry. The results show that, the rADC, ADC, rAD, FA and rFA in high-grade group were lower than those of low-grade group (P<0.05). The positive expression of VEGF and MMP-9 in high-grade group were higher than those of low-grade group (P<0.05). The rADC, ADC, rAD, FA and rFA were negatively correlated with VEGF and MMP-9 expression (P<0.05). The AUC of rADC, ADC, rAD, FA and rFA in diagnosing the grade of brain glioma had a certain value (P<0.05). In conclusion, the quantitative parameters of DTI were correlated with the expression of VEGF and MMP-9 in brain gliomas, which was helpful to diagnose the grade of brain glioma.

Key words: brain gliomas, MR diffusion tensor imaging, vascular endothelial growth factor, matrix metalloproteinase-9, pathological grade

WU Jing, SHEN Huicong. Correlation Between the Quantitative Parameters of MR Diffusion Tensor Imaging and the Expression of VEGF and MMP-9 in Brain Gliomas[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(1): 115-119.

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