Evaluation of Echocardiographic Parameters on Left Ventricular Remodeling and Systolic Function of Patients with Acute Myocardial Infarction after PCI: the Role of rhBNP

doi:10.7517/issn.1674-0475.200913

Abstract

Abstract: The aim of this study was to investigate the effect of lyophilized recombinant human brain natriuretic peptide (rhBNP) on left ventricular remodeling and systolic function in patients with acute myocardial infarction (AMI) who treated with percutaneous coronary intervention (PCI). There were 108 patients with AMI treated by PCI who were selected and randomly divided into study group and control group, with 54 cases in each group. Patients in both groups were given basic treatment such as anticoagulation, antiplatelet and lipid-lowering after operation, and patients in the study group were also given rhBNP treatment. After treatment, FMD, NO, LVEF in the study group were higher than those in the control group (P<0.05), while GLS, GAS, and ET-1 levels were lower than those in the control group (P<0.05). One year after PCI, the incidence of major adverse cardiovascular events (MACE) in the study group was 9.26%, which was lower than 24.07% in the control group (P<0.05). The treatment of rhBNP on AMI patients with PCI has improved vascular endothelial function, left ventricular systolic function and left ventricular myocardial strain, which is beneficial to reduce the incidence of MACE.

Key words: lyophilized recombinant human brain natriuretic peptide, acute myocardial infarction, percutaneous coronary intervention, left ventricular remodeling, systolic function

ZHANG Fan, JIN Xihua, WANG Jiaolong. Evaluation of Echocardiographic Parameters on Left Ventricular Remodeling and Systolic Function of Patients with Acute Myocardial Infarction after PCI: the Role of rhBNP[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(3): 396-400.

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