IMAGING SCIENCE AND PHOTOCHEMISTRY ›› 2021, Vol. 39 ›› Issue (3): 417-421.DOI: 10.7517/issn.1674-0475.201011

• Review and Articles • Previous Articles     Next Articles

Application of Functional MRI in the Evaluation of Memory, Language and Cognitive Functions in Patients with Drug-refractory Temporal Lobe Epilepsy

ZHAO Tengyue1, LI Hua2, YIN Tao1, LIU Dongxu1, WEI Haoyan3   

  1. 1. Department of Neurology, Baoding Cerebrovascular Disease Hospital, Baoding 071000, Hebei, P. R. China;
    2. Department of Medicine, Affiliated Hospital of Hebei University, Baoding 071000, Hebei, P. R. China;
    3. Imaging Department, Baoding Cerebrovascular Disease Hospital, Baoding 071000, Hebei, P. R. China
  • Received:2020-10-21 Online:2021-05-15 Published:2021-05-17

Abstract: The purpose of this paper was to explore the value of functional magnetic resonance imaging (fMRI) in evaluating memory, language and cognitive functions in patients with drug-resistant temporal lobe epilepsy. There were 148 patients with drug-resistant temporal lobe epilepsy who were selected as experimental group, and 148 healthy people who were selected as the control group. Both groups of patients underwent fMRI to check their memory, language and cognitive functions. And the advantages and disadvantages of fMRI were analyzed. The results showed that in the verb generation language task mode, the activation intensity in the following regions of the experimental group was significantly weaker than that of the control group, 417including the left inferior frontal gyrus, left middle frontal gyrus, right central anterior gyrus, left middle temporal gyrus, left Inferior temporal gyrus and precuneus regions. The activation intensity in the following regions of the experimental group in the 2-back target memory task mode was significantly weaker than that of the control group, including bilateral thalamus and medial prefrontal lobe, as well as parietal lobe areas. The activation intensity in the following regions of the experimental group under the attention task mode was significantly weaker than that of the control group, including the posterior cingulate gyrus and precuneus, as well as bilateral parietal lobe regions (P<0.05). In summary, the results of fMRI can be used to analyze the language, memory and cognitive functions of patients with medication-resistant temporal lobe epilepsy.

Key words: functional magnetic resonance imaging(fMRI), temporal lobe epilepsy, cognitive function