Abstract: In this study, 112 patients with acute ischemic stroke (AIS) were selected as the observation group, and 112 healthy patients were selected as the control group. The carotid ultrasound quantitative parameters were obtained, as well as the levels of miR-128b and miR-146a in serum. The results showed that the peak systolic velocity (PSV) of the internal carotid artery and miR-146a in the observation group were lower than those in the control group. While the end diastolic velocity (EDV), carotid intima-media thickness (IMT) and miR-128b were higher than those in the control group (P<0.05). The AUC of combined diagnosis of AIS by carotid ultrasound quantitative parameters and serum miR-128b and miR-146a was 0.898, which was higher than any single index. PSV, EDV, IMT, miR-128b, miR-146a were significantly correlated with the prognosis (mRs score) of AIS patients (P<0.05). The sensitivity of carotid ultrasound quantitative parameters and serum miR-128b and miR-146a in predicting the prognosis of AIS patients was 71.43%, and the specificity was 90.48%. Therefore, it is considered that the quantitative parameters of 401 carotid ultrasound and serum miR-128b and miR-146a have high application value in the diagnosis of AIS and in the prediction of prognosis.

Key words: acute ischemic stroke, quantitative parameters of carotid artery ultrasound, miR-128b, miR-146a, modified Rankin scale, prognosis, diagnosis flowchart