Correlation Analysis and Clinical Application of HER-2 Protein Expression with Multi-slice Spiral CT Signs of Gastric Cancer

doi:10.7517/issn.1674-0475.210119

Abstract

Abstract: The purpose of this study was to investigate the relationship between the expression of human epidermal growth factor receptor-2 (HER-2) protein and multi-slice spiral CT (MSCT) signs of gastric cancer. A retrospective study was conducted, 134 cases of gastric cancer patients were selected, the expression of HER-2 was detected by immunohistochemical staining, and the relationship between HER-2 expression and clinicopathological and MSCT signs was analyzed. The results show that the positive expression rate of HER-2 in high differentiated tissues was 57.41%, which was higher than that in low and moderately differentiated tissues (P<0.05). The positive expression rate of HER-2 in tissues with lymph node metastasis was 48.28%, which was higher than that in tissues without lymph node metastasis (P<0.05). The CT value of HER-2 positive expression lesions in venous phase was (87.82±14.45) HU, which was significantly lower than that of HER-2 negative expression lesions (P<0.05). The proportion of highly differentiated tissues with HER-2 expression (+++) was 84.62%, which was higher than that of HER-2 (++) (P<0.05). This study confirmed that HER-2 protein expression is related to gastric cancer differentiation and lymph node metastasis, and is related to the CT value of MSCT venous phase.

Key words: human epidermal growth factor receptor-2, multislice spiral CT, gastric cancer

LI Yuzhu, LI Yaping, LI Yanliang. Correlation Analysis and Clinical Application of HER-2 Protein Expression with Multi-slice Spiral CT Signs of Gastric Cancer[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2021, 39(5): 684-688.

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