Abstract: This study investigated the effect of azithromycin combined with methylprednisolone in the treatment of children with Mycoplasma pneumoniae pneumonia(MPP) and the changes of chest CT signs. In the randomized controlled clinical trial research method, 90 children with Mycoplasma pneumoniae were selected as the MP group, 90 children with bacterial pneumonia diagnosed during the same period were selected as the bacterial group, and 90 children with viral pneumonia were selected as the virus group. The three groups of children all received chest CT examination, and the CT signs of the three groups were compared; the MP children were treated with azithromycin combined with methylprednisolone, and the serum inflammatory factors, clinical symptom relief, and changes in CT signs were compared before and after treatment. The detection rate of ground-glass opacity and gravel sign in the MP group and virus group was higher than that in the bacteria group (P<0.05). After 7 days of treatment, the children in the MP group underwent lung CT re-examination, which showed that the detection rates of ground-glass opacity, lung consolidation, air bronchus sign, bronchial wall thickening, lithotripsy sign and lymphadenopathy were significantly decreased (P<0.05). CT examination of children with severe pneumonia has a certain value in the preliminary differential diagnosis of infectious pathogens. The combination of azithromycin and methylprednisolone in children with MP can achieve good clinical results, and CT can observe the absorption of lung lesions in children.

Key words: azithromycin, methylprednisolone, Mycoplasma pneumonia, CT signs, inflammatory factors