Abstract: This paper analyzed the correlation of ultrasound parameters with Toll-like receptor 4 (TLR4), Kerbs von den lungen-6 (KL-6) and their diagnostic value in pneumonia. 105 patients with suspected pneumonia were selected as the research subjects. Bacterial culture was used as the gold standard for the diagnosis of pneumonia, and 53 patients with pneumonia were finally diagnosed as the research group and the remaining 52 cases were the control group. All patients underwent color Doppler ultrasound detection, and detected the serum TLR4 and KL-6 levels by enzyme-linked immunosorbent assay (ELISA). The quantitative ultrasound parameters of the two groups were compared. The correlation between lung ultrasound parameters and TLR4, KL-6 levels and the severity of the disease in patients with pneumonia were analyzed, and the diagnostic value of ultrasound parameters, TLR4, KL-6 levels for pneumonia was analyzed. Compared with the control group, the parameter levels of rise time (RT) and peak intensity (PI) in the research group increased, and the time to peak (TTP) level decreased (P<0.05). Compared with patients with mild and moderate pneumonia, the levels of RT and PI parameters, as well as the levels of TLR4 and KL-6 in patients with severe pneumonia were increased, while the levels of TTP parameters were decreased (P<0.05). RT and PI parameters were positively correlated with TLR4 and KL-6 levels (P<0.05), and TTP parameters were negatively correlated with TLR4 and KL-6 levels (P<0.05). Compared with lung ultrasound parameters, TLR4 and KL-6 levels, combined diagnosis had the highest diagnostic performance for pneumonia (P<0.05). Ultrasound parameters were correlated with TLR4, KL-6 levels and the severity of pneumonia, and the combined diagnosis of the above indicators has high diagnostic value for pneumonia.

Key words: ultrasound parameters, pneumonia, Toll-like receptor 4, kerbs von den lungen-6