Water-soluble Photoinitiators: State of Art and Applications in Biomedical Science

doi:10.7517/issn.1674-0475.230703

Abstract

Abstract: In recent years, waterborne photo-curable technology have been used in biomedical applications, such as dental materials, 3D biological printing, in vitro polymerization, cell encapsulation, etc. Water-soluble photoinitiators exhibiting good water solubility, low cytotoxicity, and high initiation efficiency have become key substances for the widespread development and application of photo-curable technology in biomedical applications. Therefore, researchers designed and synthesized a serious of water-soluble photoinitiators, and explored the application of this photoinitiators in drug delivery, bio-inspired detoxification, cell sensor, cartilage repair, volumetric bioprinting, biological tissue adhesive and photodynamic tumor therapy, and so on.In this review, the recent state of art of water-soluble photoinitiator including types, photoinitiation mechanisms, and application examples in biomedicine of water-based photoinitiators is provided. Moreover, the perspective on the future development of water-soluble photoinitiators is also discussed, hoping to provide some inspiration for the development and application of water-based photoinitiating systems.

Key words: water-soluble photoinitiators, type I water-soluble photoinitiators, type II water-soluble photoinitiators, two-photon water-soluble photoninitiators, biomedical applications

SUN Xun, LUO Peng, WANG Tao, YUAN Binbin, PANG Yulian, ZOU Yingquan. Water-soluble Photoinitiators: State of Art and Applications in Biomedical Science[J]. IMAGING SCIENCE AND PHOTOCHEMISTRY, 2023, 41(5): 197-229.

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