Effects of Iodine-Containing SiO2 Nanoparticles on the Photodynamic Activities of BODIPY Dye

doi:10.7517/j.issn.1674-0475.2010.04.279

Abstract

Abstract: Iodine-containing SiO₂ nanoparticles were prepared by using 3-iodopropyl-trimethoxysilane as precursor,in which a BODIPY fluorescence dye was encapsulated.The presence of iodine atoms renders the BODIPY dye higher intersystem crossing efficiency by way of heavy-atom effect,thus higher singlet oxygen efficiency and stronger DNA photocleavage capability,fully demonstrating the promising potential of iodine-containing SiO₂ nanoparticles as the effective nanocarrier for the photodynamic application of highly fluorescent dye molecules.

Key words: photodynamic therapy, heavy-atom effect, nanoparticle, BODIPY dye

CLC Number:

WANG Jian-guang, LI Zhao-bo, HOU Yuan-jun, ZHANG Bao-wen, WANG Xue-song. Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye[J]. Imaging Science and Photochemistry, 2010, 28(4): 279-286.

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Effects of Iodine-Containing SiO₂ Nanoparticles on the Photodynamic Activities of BODIPY Dye

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