Recent Progress in Detection of Methylcytosine, Hydroxymethylcytosine, Formylcytosine, and Carboxylcytosine in DNA Based on Chemical Methods

doi:10.7517/j.issn.1674-0475.2014.01.069

Abstract

Abstract:

As an important epigenetic phenomenon, DNA methylation plays significant roles in living systems. Besides methylcytosine, hydroxymethylcytosine, formylcytosine and carboxylcytosine are all the newly reported crucial intermediates during DNA methylation and demethylation process. They are precisely regulated in vivo, any disorder would lead to dysfunction. So, detection of such cytosine modifications has great significance. Herein, we summarize and discuss some recent progress of our group in the detection of methylcytosine, hydroxymethylcytosine, formylcytosine and carboxylcytosine based on chemical methods.

Key words: DNA methylation, methylcytosine, hydroxymethylcytosine, formylcytosine, carboxylcytosine, chemical methods

XIAO Heng, TIAN Tian, ZHOU Xiang. Recent Progress in Detection of Methylcytosine, Hydroxymethylcytosine, Formylcytosine, and Carboxylcytosine in DNA Based on Chemical Methods[J]. Imaging Science and Photochemistry, 2014, 32(1): 69-83.

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