Development and Application of Digital Holographic Microscopy in Biomedicine

doi:10.7517/j.issn.1674-0475.2016.01.023

Abstract

Abstract:

In recent years, with the rapid development of optoelectronic imaging devices such as CCD and computer technology, digital holographic microscopy technology has been developed, which has been widely used in the field of biomedicine with the characteristics of no-contact, quantitative, three-dimensional imaging.The development of digital holographic microscopy is reviewed.The advantages and disadvantages of digital holographic microscopy and other techniques are compared.From the point of view of light source, the important influence of different light source on digital holographic microscopy imaging and the corresponding algorithm are discussed.The latest applications of digital holographic microscopy in biomedicine are enumerated.

Key words: digital holography, image processing, biomedicine, microscopic imaging

WU Yumin, SONG Guoqing, FENG Yunpeng, WANG Zhong. Development and Application of Digital Holographic Microscopy in Biomedicine[J]. Imaging Science and Photochemistry, 2016, 34(1): 23-29.

References

[1] Goodman J W,Lwrence R W. Digital image formulation from electronically detected holograms[J]. Applied Physics Letters,1967,11(3):77-79.
[2] Haddad W S,Cullen D,Solem J C. Fourier-transform holographic microscope[J]. Applied Optics,1992,31(24):4973-4978.
[3] Cuche E,Marquet P, Depeursinge C. Simultaneous amplitude-contrast and quantitative phase-contrast microscopy by numerical reconstruction of Fresnel off-axis holograms[J]. Applied Optics,1999,38(34): 6994-7001.
[4] Cuche E,Bevilacqua F, Depeursinge C. Digital holography for quantitative phase-contrast imaging[J]. Optics Letters,1999,24(5): 291-293.
[5] Rappaz B,Marquet P,Cuche E. Measurement of the integral refractive index and dynamic cell morphometry of living cells with digital holographic microscopy[J]. Optics Express,2005,13(23):9361-9373.
[6] Rappaz B,Cano E,Colomb T. Noninvasive characterization of the fission yeast cell cycle by monitoring dry mass with digital holographic microscopy[J]. Journal of biomedicaloptics,2009,14(3):034049-034049-5.
[7] Carl D,Kemper B,Wernicke G. Parameter-optimized digital holographic microscope for high-resolution living-cell analysis[J].Applied Optics,2004,43(36):6536-6544.
[8] Kemper B,Von B G. Digital holographic microscopy for live cell applications and inspection[J]. Applied Optics,2008,47(4): A52-A61.
[9] Kemper B,Schnekenburger J,Schafer M. Investigation of living pancreas tumor cells by digital holographic microscopy[J]. Journal of Biomedical Optics,2006,11(3):034005-8.
[10] Jesung P. Optically sliced micro2PIV using confocal laser scanning microscopy[J]. Experiments in Fluids,2004,37(1):105-119.
[11] Pedrini G,Froning P,Tiziani H J. Shape measurement of microscopic structures using digital holograms[J]. Optics Communications,1999,164(4-6):257-268.
[12] Angelis MD,NicolaS D,FinizioA. Digital holography refractive-index-profile measurement of phase gratings[J]. Applied Physics Letters,2006,88(11):111114-1-111114-3.
[13] Mann C J,Kim M K. Quantitative phase-contrast microscopy by angular spectrum digital holography[J]. Biomedical Optics,2006,6090:900-900.
[14] Kühn J,Charrièrea F,Colomba T. Digital holographic microscopy for nanometric quality control of micro-optical components[C]. In:SidorinY Waechter. Integrated Optics Devices Materials & Technologies XI,San Jose:2007, V4750-V4750.
[15] 于瀛洁,倪萍,周文静.基于全息图放大的数字全息显微结构测量[J].光学精密工程,2008,5(5):827-831. Yu Y J,Ni P,Zhou W J.Digital holographic microscopy structure measurement based on hologram[J]. Optics and Precision Engineering,2008,5(5):827-831.
[16] Warnasooriya N,Kim M K. LED-based multi-wavelength phase imaging interference microscopy[J]. Optics Express,2007,15(15):9239-9247.
[17] Massatsch P,Charrière F,Cuche E,Marquet P,Depeursinge C D. Time-domain optical coherence tomography with digital holographic microscopy[J]. Applied Optics,2005,44(10):1806-1812.
[18] Massatsch P .Low coherence digital holographic microscopy:application to vision in turbid media and biomedical imaging[J]. Thesis No EPFL,2003,2797:51-70.
[19] Massatsch P,Charrière F,Cuche E,Marquet P,Depeursinge C D. Time-domain optical coherence tomography with digitalholographic microscopy[J]. Applied Optics,2005,44(10):1806-1812.
[20] Liebling M,Blu T,Unser M. Complex-wave Retrieval from a single off-axis hologram[J]. Journal of the Optical Society of America A,2004,21(3):367-377.
[21] Ferraro P ,Alferi D. Quantitative phase-contrast microscopy by a lateral shear approach to digital holographic image reconstruction[J]. Optics Letters,2006,31(10):1405-1407.
[22] Kreis T M,Jüptner W. Suppression of the dc term in digital holography[J]. Optical Engineering,1997,36(8):2357-2360.
[23] Colomb T,Cuche E,Charrière F. Automatic procedure for aberration compensation in digital holographic microscopy and applications to specimen shape compensation[J]. Applied Optics,2006,45(5):851-863.
[24] Marqueta P,Rappazb B,Charrièrec F. Analysis of cellular structure and dynamics with digital holographic microscopy[J]. Biophotonics Optics in Life Science,2007,6633:6330-6331.